Aging of the Genome
The Dual Role of DNA in Life and Death
By (author) Jan Vijg
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Aging of the Genome by Jan Vijg
Book DescriptionAging has long since been ascribed to the gradual accumulation of DNA mutations in the genome of somatic cells. However, it is only recently that the necessary sophisticated technology has been developed to begin testing this theory and its consequences. Vijg critically reviews the concept of genomic instability as a possible universal cause of aging in the context of a new, holistic understanding of genome functioning in complex organisms resulting from recent advances in functional genomics and systems biology. It provides an up-to-date synthesis of current research, as well as a look ahead to the design of strategies to retard or reverse the deleterious effects of aging. This is particularly important in a time when we are urgently trying to unravel the genetic component of aging-related diseases. Moreover, there is a growing public recognition of the imperative of understanding more about the underlying biology of aging, driven by continuing demographic change.
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Book DetailsISBN: 9780198569220
(252mm x 195mm x 25mm)
Imprint: Oxford University Press
Publisher: Oxford University Press
Publish Date: 25-Jan-2007
Country of Publication: United Kingdom
Books By Author Jan Vijg
Aging of the Genome, Paperback (January 2007)» View all books by Jan Vijg
Aging has long since been ascribed to the gradual accumulation of DNA mutations in the genome of somatic cells. This book reviews the concept of genomic instability. It provides underlying biology of aging, driven by continuing demographic change.
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Author Biography - Jan Vijg
Jan Vijg is Professor at the Buck Institute for Age Research in Novato, California, USA
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