Animal and Translational Models for CNS Drug Discovery: Psychiatric Disorders by Robert A. McArthur
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Animal and Translational Models for CNS Drug Discovery: Psychiatric Disorders
By Robert A. McArthur

Animal and Translational Models for CNS Drug Discovery: Psychiatric Disorders

Edited by See other recent books by Robert A. McArthur See other recent books by Franco Borsini
Format: Hardback

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Animal and Translational Models for CNS Drug Discovery: Psychiatric Disorders by Robert A. McArthur

Book Description

"Psychiatric Disorders" is written for researchers in both academia and the pharmaceutical industry who use animal models in research and development of drugs for psychiatric disorders such as anxiety, obsessive-compulsive disorder, depression, schizophrenia, bipolar disorder, ADHD, and autistic spectrum disorder. "Psychiatric Disorders" has introductory chapters expressing the view of the role and relevance of animal models for drug discovery and development for the treatment of psychiatric disorders from the perspective of: academic basic neuroscientific research, applied pharmaceutical drug discovery and development, and issues of clinical trial design and regulatory agencies limitations. Each volume examines the rationale, use, robustness and limitations of animal models in each therapeutic area covered and discuss the use of animal models for target identification and validation. The clinical relevance of animal models is discussed in terms of major limitations in cross-species comparisons, clinical trial design of drug candidates, and how clinical trial endpoints could be improved. The aim of this series of volumes on "Animal and Translational Models for CNS Drug Discovery" is to identify and provide common endpoints between species that can serve to inform both the clinic and the bench with the information needed to accelerate clinically-effective CNS drug discovery. This is the first volume in the three volume-set, "Animal and Translational Models for CNS Drug Discovery" (9780123738615), and is also available for purchase individually. It provides clinical, academic, government and industry perspectives fostering integrated communication between principle participants at all stages of the drug discovery process. It offers critical evaluation of animal and translational models improving transition from drug discovery and clinical development. It emphasizes what results mean to the overall drug discovery process. It explores issues in clinical trial design and conductance in each therapeutic area. "Psychiatric Disorders" is available for purchase individually.

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Book Details

ISBN: 9780123738561
ISBN-10: 0123738563
Format: Hardback
(260mm x 184mm x 33mm)
Pages: 528
Imprint: Academic Press Inc
Publisher: Elsevier Science Publishing Co Inc
Publish Date: 17-Nov-2008
Country of Publication: United States

Books By Author Robert A. McArthur

Translational Neuroimaging by Robert A. McArthur Translational Neuroimaging, Hardback (December 2012)

Examines the translational role of neuroimaging in model development from preclinical animal models, to human experimental medicine, and finally to clinical studies. This book provides common endpoints between species that can serve to inform the clinic and bench with the information needed to accelerate clinically-effective CNS drug discovery.

Animal and Translational Models for CNS Drug Discovery: Neurological Disorders by Robert A. McArthur Animal and Translational Models for CNS Drug Discovery: Neurological Disorders, Hardback (November 2008)

Suitable for researchers in academia and pharmaceutical industry who use animal models in research and development of drugs for neurological disorders, this title identifies and provides common endpoints between species that can serve to inform the clinic and the bench with information needed to accelerate clinically-effective CNS drug discovery.

Animal and Translational Models for CNS Drug Discovery: Reward Deficit Disorders by Robert A. McArthur Animal and Translational Models for CNS Drug Discovery: Reward Deficit Disorders, Hardback (November 2008)

Suitable for researchers in academia and pharmaceutical industry who use animal models in research and development of drugs for reward deficit disorders, this title identifies and provides common endpoints between species that can serve to inform the clinic and bench with information needed to accelerate clinically-effective CNS drug discovery.

» View all books by Robert A. McArthur

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Author Biography - Robert A. McArthur

Dr. McArthur began his professional career investigating the role of serotonin on feeding behaviour at the Clarke Institute of Psychiatry in Toronto, Canada. This interest led him to complete a PhD in the psychopharmacology of feeding behaviour and macronutrient selection with John Blundell at the University of Leeds, Leeds, UK. In 1981 he joined Beecham Pharmaceuticals to work on adrenergic involvement in energy expenditure and obesity. In 1983 Dr McArthur began working on M1 functional agonists for the treatment of Alzheimer disease and was responsible for demonstrating the initial procognitive effects of Sabcomeline. Following the merger of Beecham with SmithKline French, Dr McArthur was appointed Business Development Executive at I.T.E.M-Labo, Paris working with Roger Porsolt in behavioural pharmacology contract research. In 1992, Robert was appointed Head of Behavioral Pharmacology at Farmitalia Carlo Erba, later Pharmacia in Milan. His lab was responsible for the preclinical behavioural pharmacology of Sabcomeline (Alzheimer's and schizophrenia); Safinamide (epilepsy and Parkinson's); Reboxetine (depression); Cabergoline (Parkinson's); Nicergoline (Mild Cognitive Impairment); and Amperozide (alcoholism). He is listed as an inventor in 19 issued patents and applications of which he is the principal inventor in 3. In 1998, Robert transferred to the Pharmacia and Upjohn Company in Kalamazoo, Michigan where as senior behavioural pharmacologist responsible, he worked on mutant mouse characterizations, the establishment of a primate unit assessing cognitive changes in monkeys (CANTAB), and development of anxiety models in marmosets. Soon after the merger of Pharmacia and Upjohn with Monsanto-Searle, Robert returned to Europe where in 2001 he founded the consulting company, McArthur and Associates GmbH in Basel. Robert has since worked on a series of projects for both large Pharma as well as biotechs, including further primate work in Parkinson's, development of behavioural pharmacology expertise, novel target validation, due diligence, medical writing, strategy evaluation, scientific advisor and as an expert witness. Dr McArthur has pursued his academic interests in translational neuroscience. In 2003, Robert was appointed as a visiting Associate Research Professor in the Department of Neuroscience (Division of Behavioural Neuroscience) at the Karolinska Institute in Stockholm. He has written and co-edited extensively on the subject of the clinical and translational relevance of animal models of CNS disorders. He has authored 43 peer-reviewed papers, 13 book chapters, co-author on 1 book and senior editor of a three-volume set on translational value of animal models for CNS drug discovery. He has served as section editor (CNS) for Current Opinion in Investigational Drugs and is on the editorial board of Drugs of the Future. In 2009 he was appointed an independent scientific expert evaluator for the European FP7-Health call. Franco Borsini, Head, Central & Peripheral Nervous System and General Pharmacology Area - R&D Department, sigma-tau SpA, Pomezia (Rome), Italy

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Recent books by Robert A. McArthur close
Translational Neuroimaging by Robert A. McArthur
Animal and Translational Models for CNS Drug Discovery: Neurological Disorders by Robert A. McArthur
Animal and Translational Models for CNS Drug Discovery: Reward Deficit Disorders by Robert A. McArthur
»
Recent books by Franco Borsini close
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»
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