Advances and Problems
Normal Price: $160.13
Your Price: $144.12 AUD, inc. GST
Shipping: $7.95 per order
You Save: $16.01! (10% off normal price)
Plus...earn $7.21 in Boomerang Bucks
Availability: Available, ships in 10-12 days
Antiviral Agents by Ernst Jucker
Book DescriptionIn the treatment of infections caused by rapidly mutating viruses like human immunodeficiency virus (HIV), combination therapy with multiple drugs act- ing by different mechanisms offers several advantages over monotherapy. It may provide: synergistic effect, possible reduction of dosages and side-effects, and reduction of the chance of drug resistance. In the past few years, hun- dreds of HIV protease inhibitors have been synthesized and tested in order to overcome the limitations of reverse transcriptase inhibitors like zidovudine and others. In this review, emphasis is placed on the development of HIV pro- tease inhibitors as antiviral agents against HIY, and structure-activity rela- tionship analysis of saquinavir and related compounds. Limitations of some protease inhibitors and ways to overcome the shortcomings are presented. Among these many protease inhibitors five have been marketed during 1995-1999. They are saquinavir, ritonavir, indinavir, nelfinavir and ampre- navir. Their different structural features, important physicochemical, phar- macokinetic and clinical profiles are presented in a table form for easy com- parison. It is hoped that in the future new drugs based on additional mech- anisms can be developed for the treatment of AIDS. Contents 4 1 Introduction ...HIV protease as a target for chemotherapy ...2 5 Design of protease inhibitors ...3 5 Basis of rational design of HIV protease inhibitors ...3.1 5 New development of HIV protease inhibitors ...6 3.2 HIV protease inhibitors on the market ...20 4 20 4.1 SAR of saquinavir and related compounds ...
Buy Antiviral Agents book by Ernst Jucker from Australia's Online Bookstore, Boomerang Books.
Book DetailsISBN: 9783764365479
(244mm x 170mm x 14mm)
Imprint: Birkhauser Verlag AG
Publisher: Birkhauser Verlag AG
Publish Date: 1-Jun-2001
Country of Publication: Switzerland
» Have you read this book? We'd like to know what you think about it - write a review about Antiviral Agents book by Ernst Jucker and you'll earn 50c in Boomerang Bucks loyalty dollars (you must be a member - it's free to sign up!)
Bestselling Books: Our Current Bestsellers | Australia's Hottest 1000 Books | Bestselling Fiction | Bestselling Crime Mysteries and Thrillers | Bestselling Non Fiction Books | Bestselling Sport Books | Bestselling Gardening and Handicrafts Books | Bestselling Biographies | Bestselling Food and Drink | Bestselling History | Bestselling Travel Books | Bestselling School Textbooks & Study Guides | Bestselling Children's General Non-Fiction | Bestselling Young Adult Fiction | Bestselling Children's Fiction | Bestselling Picture Books | Top 100 US Bestsellers
Phone: 1300 36 33 32 (9am-2pm Mon-Fri AEST) - International: +61 2 9960 7998 - Online Form
Address: Boomerang Books, 878 Military Road, Mosman Junction, NSW, 2088
© 2003-2016. All Rights Reserved. Eclipse Commerce Pty Ltd - ACN: 122 110 687 - ABN: 49 122 110 687
For every $20 you spend on books, you will receive $1 in Boomerang Bucks loyalty dollars. You can use your Boomerang Bucks as a credit towards a future purchase from Boomerang Books. Note that you must be a Member (free to sign up) and that conditions do apply.