Biochemistry of Drug Metabolism by Bernard Testa
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Biochemistry of Drug Metabolism
By Bernard Testa

The Biochemistry of Drug Metabolism

Principles, Redox Reactions, Hydrolyses Principles, Redox Reactions, Hydrolyses v. 1

By (author) See other recent books by Bernard Testa See other recent books by Stefanie D. Kramer
Format: Paperback

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Biochemistry of Drug Metabolism by Bernard Testa

Book Description

The first of the two volumes is divided into three parts. Part One begins by introducing xenobiotics in the broad context of physiological metabolism, and continues with an overview of the processes of drug disposition and metabolism. It then goes on to summarize the macroscopic and microscopic locations of drug metabolism in animals and humans. This is followed by an introduction to the all-important issue of the consequences of drug and xenobiotic metabolism, providing an initial overview of pharmacokinetic, pharmacological and toxicological consequences. The last chapter examines drug metabolism in the context of drug research, with a focus on medicinal chemistry. The second part is a major component of the book, corresponding to the role of oxidoreductases as major agents of metabolism. Cytochromes P450 receive particular attention, namely their multiplicity, structure, catalytic mechanisms, and the various reactions they catalyze, while other oxidoreductases are also presented, such as flavin monooxygenases, monoamine oxidases and other amine oxidases, aldehyde oxidase and xanthine dehydrogenase, peroxidases, and dehydrogenases-reductases. Each drug-metabolizing enzyme or enzyme family begins with an Enzyme Identity Card summarizing its nomenclature and biochemical essentials. Part Three begins with a survey of the classification, properties and catalytic mechanism of the innumerable hydrolases known or suspected to play a role in xenobiotic metabolism. The focus then shifts to a systematic presentation of the various substrate classes, namely carboxylic esters, amides and peptides, lactams and lactones, esters of inorganic acids, alkene and arene epoxides, and some miscellaneous hydrolyzable moieties. With a foreword by Prof Leslie Z. Benet, the world's best and best-known biopharmaceutical scientist

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Book Details

ISBN: 9783906390536
ISBN-10: 3906390535
Format: Paperback
(242mm x 171mm x 18mm)
Pages: 332
Imprint: Helvitica Chimica Acta Verlag,Switzerland
Publisher: Helvitica Chimica Acta Verlag,Switzerland
Publish Date: 13-Feb-2008
Country of Publication: Switzerland

Other Editions...


Books By Author Bernard Testa

Organic Stereochemistry by Bernard Testa Organic Stereochemistry, Paperback (April 2014)

"This book should become an indispensable asset on the bookshelves of pharmaceutical laboratories in academia and in industry, as well as of laboratories devoted to plant protection. I am convinced that studying this book will be an eye-opener for many scientists in the field of life sciences.

Biochemistry of Drug Metabolism by Bernard Testa Biochemistry of Drug Metabolism, Paperback (March 2010)

Volume Two contains the last four parts of this work. Part 4 is devoted to the huge field of conjugation reactions, with much information being given on transferases. As in the two preceding parts, each drug-metabolizing enzyme or enzyme family begins with an Enzyme Identity Card summarizing its nomenclature and biochemical essentials.

Drug Bioavailability by Bernard Testa Drug Bioavailability, Hardback (October 2008)

The gold standard for industrial research now completely revised in line with current trends in the field, with all contributions extensively updated or rewritten. In 21 chapters readers can benefit from the key working knowledge of today's leading pharmaceutical companies, including Pfizer, AstraZeneca, and Roche.

Pharmacokinetic Profiling in Drug Research by Bernard Testa Pharmacokinetic Profiling in Drug Research, Hardback (February 2006)

Informatics and robotics are the workhorses of a technological revolution in drug research. On them are based combinatorial chemistry, which yields compounds by the many thousands, and high-throughput bioassays, which screen them for activity. The results are avalanches of 'hits', which invade the databases like swarms of locusts.

» View all books by Bernard Testa

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Recent books by Bernard Testa close
Organic Stereochemistry by Bernard Testa
Biochemistry of Drug Metabolism by Bernard Testa
Biochemistry of Drug Metabolism by Bernard Testa
Drug Bioavailability by Bernard Testa
Pharmacokinetic Profiling in Drug Research by Bernard Testa
»
Recent books by Stefanie D. Kramer close
Biochemistry of Drug Metabolism by Stefanie D. Kramer
Biochemistry of Drug Metabolism by Stefanie D. Kramer
Biochemistry of Drug Metabolism by Stefanie D. Kramer
Pharmacokinetic Profiling in Drug Research by Stefanie D. Kramer
»
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