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Cardiovascular Development by Paul M. Wassarman
Book DescriptionIn 1993, Rolf Bodmer described a gene he named tinman that was required for the formation of the dorsal aorta of the fly. Flies without a functional tinman gene had no heart. Quickly, mammalian counterparts of the tinman gene were identified and found to be expressed by early cardiomyogenic precursors and by cardiomyocytes throughout heart development. Since then, significant progress has been made in the understanding of molecular and genetic determinants of heart formation. An ever growing number of genes have been identified that are required for cardiogenesis, as evidenced by severe abnormalities in cardiac development produced by inactivation in the mouse or inhibition of gene function in other model organisms."Cardiovascular Development" covers some of the latest research in the study of heart formation. Volume Editor Rolf Bodmer has assembled a world-class list of contributors whose research uses a variety of animal models and whose findings are certain to enhance our understanding of this exciting field. This volume ties together the development of heart morphology and conduction system. It presents the latest developments in vertebrate and invertebrate genetic model systems. It describes technological advancements in cardiovascular science.
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Book DetailsISBN: 9780444530141
(229mm x 152mm x 24mm)
Imprint: Elsevier Science Ltd
Publisher: Elsevier Science & Technology
Publish Date: 9-Oct-2007
Country of Publication: United Kingdom
Books By Author Paul M. Wassarman
Guide to Zona Pellucida Domain Proteins, Hardback (August 2015)
This book provides a coherent, clear, and uniform presentation of structural, genetic, molecular, and biochemical information available for the zona pellucida domain protein family, which impact pathologies such as infertility, deafness, and cancer.
Gametogenesis, Hardback (December 2012)
Covers the area of gametogenesis, with contributions from an international board of authors. In this book, the chapters provide a comprehensive set of reviews covering such topics as germline stem cells, signaling modalities during oogenesis in mammals, and genomic imprinting as a parental effect established in mammalian germ cells.
Guide to Techniques in Mouse Development, Hardback (September 2010)» View all books by Paul M. Wassarman
Covers various techniques for the cryopreservation of gametes and embryos, production of transgenic and null (knockout) animals (use of ES cells), generation of conditional/inducible mutant animals, use of gene-trap mutagenesis, analysis of allele-specific expression, use of new reporter constructs, humanizing of transgenic animals, and more.
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Author Biography - Paul M. Wassarman
Paul M. Wassarman, the Series Editor of CTDB since 2007, is Professor in the Dept. Developmental and Regenerative Biology at the Icahn School of Medicine at Mount Sinai in New York City. He received a Ph.D. in biochemistry from Brandeis University where he carried out thesis research in the Graduate Dept. Biochemistry with Professor Nathan O. Kaplan. In 1967 Wassarman joined the Division of Structural Studies at the MRC, Laboratory of Molecular Biology in Cambridge, England as a Helen Hay Whitney Foundation Fellow with Sir John C. Kendrew. In 1972 he joined the faculty of the Dept. Biological Chemistry at Harvard Medical School and in 1986 moved to the Roche Institute of Molecular Biology where he was Chair of the Dept. Cell and Developmental Biology and Adjunct Professor in the Dept. Cell Biology, New York University School of Medicine. In 1996 he moved to the Icahn School of Medicine at Mount Sinai where he was the Lillian and Henry M. Stratton Professorial Chair of the Dept. Molecular, Cell, and Developmental Biology. Wassarman has published more than 200 research papers and reviews, dealing primarily with mammalian oogenesis, fertilization, and early embryogenesis.
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