Chemistry and Application of H-Phosphonates
By (author) Kolio Dimov Troev
Normal Price: $467.00
Your Price: $420.30 AUD, inc. GST
Shipping: $7.95 per order
You Save: $46.70! (10% off normal price)
Plus...earn $21.02 in Boomerang Bucks
Availability: Available to Backorder, No Due Date for Supply
Chemistry and Application of H-Phosphonates by Kolio Dimov Troev
Book DescriptionChemistry and Application of H-Phosphonates is an excellent source for those planning the synthesis of new phosphorus-containing compounds and in particular derivatives containing a phosphonate, phosphoramide or phosphonic acid diester group. The rich chemistry, low cost and easy availability of diesters of H-phosphonic acid makes them an excellent choice as synthone in a number of practically important reactions. Phosphonic acid esters are intermediates in the synthesis of important classes of compounds such as alpha-aminophosphonic acids, bisphosphonates, epoxyalkylphosphonates, alpha-hydroxyalkylphosphonates, phosphoramides, poly(alkylene H-phosphonate)s, poly(alkylene phosphate)s, nucleoside H-phosphonates. The synthesis of each of these compound classes is reviewed in detail. Alpha-Aminophosphonic acids are an important class of biologically active compounds, which have received an increasing amount of attention because they are considered to be structural analogues of the corresponding Alpha-amino acids. The utilities of alpha-aminophosphonates as peptide mimics, haptens of catalytic antibodies, enzyme inhibitors, inhibitors of cancers, tumours, viruses, antibiotics and pharmacologic agents are well documented. Alpha-Hydroxyalkanephosphonates are compounds of significant biological and medicinal applications. Dialkyl epoxyalkylphosphonates are of interest because of their use as intermediates in the synthesis of bioactive substances, and as modifiers of natural and synthetic polymers. Bisphosphonates are drugs that have been widely used in different bone diseases, and have recently been used successfully against many parasites. Poly(alkylene H-phosphonate)s and poly(alkylene phosphate)s are promising, biodegradable, water soluble, new polymer-carriers of drugs. Nucleoside H-phosphonates seem to be the most attractive candidates as starting materials in the chemical synthesis of DNA and RNA fragments. The 5'-hydrogen phosphonate-3'-azido-2',3'-dideoxythimidine is one of the most significant anti-HIV prodrug, which is currently in clinical trials. Chapters review the synthesis; physical and spectral properties (1H, 13C, 31P and 17O NMR data); characteristic reactions; important classes of compounds based on these esters of H-phosphonic acid; their application as physiologically active substances, flame retardants, catalysts, heat and light stabilizers, lubricants, scale inhibitors, polymer-carriers of drugs; preparation of H-phosphonate diesters and general procedures for conducting the most important reactions. * provides ideas for the synthesis of phosphonates, phosphoramides and diesters of phosphonic acid (new phosphorus-containing compounds) * reviews structure, spectra and biological activity of H-phosphonates and their derivatives * examines new areas of application of phosphorus-containing compounds
Buy Chemistry and Application of H-Phosphonates book by Kolio Dimov Troev from Australia's Online Bookstore, Boomerang Books.
Book DetailsISBN: 9780444527370
(240mm x 165mm x 19mm)
Imprint: Elsevier Science Ltd
Publisher: Elsevier Science & Technology
Publish Date: 19-Jul-2006
Country of Publication: United Kingdom
Books By Author Kolio Dimov Troev
Polyphosphoesters, Hardback (January 2012)» View all books by Kolio Dimov Troev
Polyphosphoesters are a multifunctional, environmentally friendly, and cost-efficient material, making them an important subject. The design of this type of material plays a key role in the progress of industry, agriculture, and medicine. This book introduces the chemistry, characterization and application of polyphosphoesters.
» Have you read this book? We'd like to know what you think about it - write a review about Chemistry and Application of H-Phosphonates book by Kolio Dimov Troev and you'll earn 50c in Boomerang Bucks loyalty dollars (you must be a member - it's free to sign up!)
Author Biography - Kolio Dimov Troev
Kolio Dimov Troev completed his undergraduate work at Higher Institute of Chemical Technology, Sofia; received his doctorate in the field of organophosphorus chemistry in 1974 from the Institute of Organic Chemistry, Bulgarian Academy of Sciences with Prof. Georgy Borissov; and was awarded the scientific degree "Doctor of Science in 1985 from the Institute of Polymers. In 1988, he became Professor of Chemistry at the same Institute. He has been the founding head of the laboratory "Phosphorus-containing monomers and polymers since 1989. His research interests are the areas of organophosphorus chemistry, especially esters of H-phosphonic acid; aminophosphonates; biodegradable, biocompatible phosphorus-containing polymers; polymer conjugates; drug delivery systems. He has been a visiting professor/lecturer in the USA (Marquette University, Tulane University), Japan (Tokyo Institute of Technology, University of Tokyo, Tohoku University, Tokyo University of Science), and Germany (Duesseldorf University). He is the author of more than 150 papers in this field published in the Phosphorus, Sulfur, Silicon and Related Elements, Heteroatom Chemistry, Journal of American Chemical Society, European Polymer Journal, Polymer, Bioorganic & Medicinal Chemistry, Journal of Medicinal Chemistry, Macromolecular Rapid Communication, Polymer Degradation and Stability, Journal of Polymer Science, Part A: Polymer Chemistry, European Journal of Medicinal Chemistry, Amino Acids, Tetrahedron Letters, Macromolecules, and RSC Advances. He is also the author of two other Elsevier books, Chemistry and Application of H-phosphonates (2006) and Polyphosphoesters: Chemistry and Application (2012). He was a director of the Institute of Polymers, Bulgarian Academy of Sciences from November 2003 to February 2012.
Bestselling Books: Our Current Bestsellers | Australia's Hottest 1000 Books | Bestselling Fiction | Bestselling Crime Mysteries and Thrillers | Bestselling Non Fiction Books | Bestselling Sport Books | Bestselling Gardening and Handicrafts Books | Bestselling Biographies | Bestselling Food and Drink | Bestselling History | Bestselling Travel Books | Bestselling School Textbooks & Study Guides | Bestselling Children's General Non-Fiction | Bestselling Young Adult Fiction | Bestselling Children's Fiction | Bestselling Picture Books | Top 100 US Bestsellers
Phone: 1300 36 33 32 (9am-5pm Mon-Fri AEST) - International: +61 2 9960 7998 - Online Form
Address: Boomerang Books, 878 Military Road, Mosman Junction, NSW, 2088
© 2003-2017. All Rights Reserved. Eclipse Commerce Pty Ltd - ACN: 122 110 687 - ABN: 49 122 110 687
For every $20 you spend on books, you will receive $1 in Boomerang Bucks loyalty dollars. You can use your Boomerang Bucks as a credit towards a future purchase from Boomerang Books. Note that you must be a Member (free to sign up) and that conditions do apply.