Comprehensive Sourcebook of Bacterial Protein Toxins by Daniel Ladant
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Comprehensive Sourcebook of Bacterial Protein Toxins
By Daniel Ladant

The Comprehensive Sourcebook of Bacterial Protein Toxins

3rd Revised edition

By (author) See other recent books by Daniel Ladant See other recent books by Michel R. Popoff
Edited by Joseph E. Alouf See other recent books by Joseph E. Alouf
Format: Hardback

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Comprehensive Sourcebook of Bacterial Protein Toxins by Daniel Ladant

Book Description

This book describes the major achievements and discoveries relevant to bacterial protein toxins since the turn of the new century illustrated by the discovery of more than fifty novel toxins (many of them identified through genome screening). The establishment of the three-dimensional crystal structure of more than 20 toxins during the same period offers deeper knowledge of structure-activity relationships and provides a framework to understand how toxins recognize receptors, penetrate membranes and interact with and modify intracellular substrates. It is edited by two of the most highly regarded experts in the field from the Institut Pasteur, France. It features 14 brand new chapters dedicated to coverage of historical and general aspects of toxinology. It includes the major toxins of both basic and clinical interest are described in depth. It details applied aspects of toxins such as therapy, vaccinology, and toolkits in cell biology. Features: evolutionary and functional aspects of bacterial toxins evaluated and summarized; toxin applications in cell biology presented; therapy (cancer therapy, dystonias) discussed; vaccines (native and genetically engineered vaccines) featured; and toxins discussed as biological weapons, comprising chapters on anthrax, diphtheria, ricin etc.

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Book Details

ISBN: 9780120884452
ISBN-10: 0120884453
Format: Hardback
(279mm x 216mm x 45mm)
Pages: 1072
Imprint: Academic Press Inc
Publisher: Elsevier Science Publishing Co Inc
Publish Date: 1-Aug-2004
Country of Publication: United States

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Author Biography - Daniel Ladant

Daniel Ladant is Director of Research at French CNRS (National Center for Scientific Research) and head of the "Biochemistry of Macromolecular Interactions unit at Institut Pasteur, Paris, France. He obtained a Ph.D. in Microbiology in 1989 and a Habilitation Diriger des Recherches (HDR), in 1999 from the Universit Paris Diderot, Paris, France. His research has been mainly focused on the study of the molecular mechanisms that underlie protein-protein and protein-membrane interactions, using as a model system a bacterial toxin, the adenylate cyclase (CyaA) produced by Bordetella pertussis, the causative agent of whooping cough. CyaA is an essential virulence factor from B. pertussis, and belongs to the large family of RTX (Repeat in ToXins) cytolysins produced by diverse Gram-negative bacteria. By combining molecular genetics, biochemical and biophysical approaches, he has characterized the structure, function and biogenesis of the CyaA toxin, with a particular emphasis on deciphering the molecular basis of its original entry pathway that involves a direct translocation of its catalytic domain across the plasma membrane. Basic knowledge gained on the mechanisms of CyaA entry into eukaryotic target cells and its interaction with cellular effectors has been used to develop various applications in vaccinology and biotechnology. In particular, the natural property of the CyaA toxin to target immune cells has been exploited to create innovative vaccines capable of stimulating potent cell-mediated immune responses against specific antigens. Two CyaA-based recombinant vaccines are currently evaluated in clinical trials. D. Ladant also designed a CyaA-based two-hybrid (BACTH) technology that has been exploited for studying, in bacteria, the assembly of protein complexes, and particularly to analyze membrane associated machineries such as bacterial secretion systems or the bacterial cell division apparatus. His other research interests include the other class II bacterial adenylate cyclase toxins, such as Edema Factor (EF) from Bacillus anthracis and ExoY toxin from Pseudomonas aeruginosa, in particular to explore of the allosteric mechanisms implicated in the activation of these enzymes by eukaryotic factors. He has published more than 90 articles in peer-reviewed journals, 20 review articles or Book chapters and co-authored 11 patents. Joseph E. Alouf is Professor of Microbiology at the Pasteur Institute of Lille. He is former Head of the Department of Bacteriology and Mycology at the Pasteur Institute at Paris and Chairman of its Scientific Council. He served as Secretary General of the French Society of Immunology from 1984-1986 and President of the Federation of the European Microbiological Societies from 1989-1992. His 40-year research work relates to the field of bacterial protein toxins and immunology of infectious diseases. He is also the co-editor of several books. Michel R. Popoff, D.V.M., Ph.D. (Microbiology) from the University of Paris (1985), Habilitation Diriger des Recherches (HDR) from the University of Paris (1990), is the Head of the Anaerobic Bacteria and Toxins Unit and the Director of the National Reference Center for Anaerobic Bacteria and Botulism at Pasteur Institute, Paris, France. He is member of the French Veterinary Academy. His laboratory is focused on Clostridium toxins through genetic and biological activity analysis and has investigated the regulation of toxin synthesis in Clostridium botulinum and Clostridium tetani. In the recent years, we have analyzed the molecular mechanism of the actin depolymerizing C. sordellii lethal toxin and clostridial binary toxins, the pore-forming C. perfringens epsilon toxin, and the passage of botulinum neurotoxin through the intestinal barrier. He was co-editor of the 3 edition of the Sourcebook of Bacterial Protein Toxins Academic Press (2006).

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