Enzyme Systems That Metabolise Drugs and Other Xenobiotics
By (author) Costas Ioannides
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Enzyme Systems That Metabolise Drugs and Other Xenobiotics by Costas Ioannides
Book DescriptionThis definitive reference work describes in detail the enzyme systems that participate in the metabolism of xenobiotics, particularly medicinal drugs. Each chapter focuses on a specific enzyme system, emphasising its role in the activation and detoxication of chemicals. Aspects discussed critically include: enzyme function in the metabolism and bioactivation of xenobiotics substrate specificity tissue distribution species distribution (to include laboratory animals and humans) hormonal regulation sex differences modulation by prior exposure to other chemicals age-dependent expression pharmacogenetics and modulation by disease. Enzyme Systems that Metabolise Drugs and Other Xenobiotics will be essential reading for industrial research scientists working in the fine chemicals and pharmaceutical industries, especially those concerned with the safety evaluation of chemicals, and investigating their metabolism, pharmacokinetic characteristics and toxicological properties. The nature and scope of the book will also make it attractive to the research toxicologist and to postgraduate students studying toxicology, as well as to clinicians and pharmacists.
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Book DetailsISBN: 9780471894667
(234mm x 178mm x 37mm)
Imprint: John Wiley & Sons Ltd
Publisher: John Wiley and Sons Ltd
Publish Date: 23-Nov-2001
Country of Publication: United Kingdom
Books By Author Costas Ioannides
Nutrition and Chemical Toxicity, Hardback (September 1998)» View all books by Costas Ioannides
This book will discuss the mechanisms and current thinking of how nutritional status influences the way we respond to chemical insults and its role in the aetiology of disease. It will take a mechanistic approach to how dietary factors are related to toxicology and chemical carcinogenesis.
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