The Fetal and Neonatal Pulmonary Circulation
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Fetal and Neonatal Pulmonary Circulation by E. Kenneth Weir
Book DescriptionBirth is a sudden, traumatic transition of environments. Once the placental oxygen supply ceases, the foetus has only minutes to establish pulmonary oxygen transport, which requires not only inflation of the lungs, but also sudden and sustained changes in the lung circulation. Not long ago, research in this field was largely restricted to morphology and physiology. Now the powerful new tools of cellular and molecular biology have begun toshed light on the physiological processes in the developing lung and its supporting vasculature. In 22 chapters, three main sections explore lung growth and development, vascular cell growth and differentiation, and the mechanisms of hemodynamic control in the neonate; extensive illustrations give a comprehensive picture of pulmonary circulatory development. Factors controlling vasculogenesis and angiogenesis are described by the scientists who pioneered the field. Similarly, the intracellular signaling cascades that determine proliferation or growth inhibition of fibroblasts, smooth muscle cells, and endothelial cells are also presented in an understandable manner. Finally, the role ofsubstances, such as nitric oxide and endothelin, that control the hemodynamics of the fetal and neonatal circulations are discussed in detail, particularly in relation to the changes occurring at birth. This book will inform basic scientists as well as the clinician and student, and should be of particular interest to pediatric cardiologists, pulmonary medicine physicians, and vascular biologists.
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Book DetailsISBN: 9780879934392
(235mm x 163mm x 28mm)
Imprint: Blackwell Futura
Publisher: John Wiley and Sons Ltd
Publish Date: 26-Apr-2000
Country of Publication: United Kingdom
Books By Author E. Kenneth Weir
Interactions of Blood and the Pulmonary Circulations, Hardback (March 2002)
A thorough exploration of the interaction between erythrocytes, leukocytes, platelets, and the pulmonary vasculature in a variety of disease states--an important topic not addressed by other books.
Oxygen Regulation of Ion Channels and Gene Expression, Hardback (June 1998)
This text provides a detailed overview of how and why a lack of oxygen occurs in organisms, exploring the mechanisms whereby oxygen interacts with living cells, but particularly focusing upon the biochemical and physiological adaptations of hypoxia and their biological and medical relevance.
Nitrate Oxide and Radicals in the Pulmonary Vasculature, Hardback (April 1996)» View all books by E. Kenneth Weir
This publication is unique and ground breaking because no previous volume has focused on the mechanisms by which nitric oxide and oxygen radicals are involved in vascular pathophysiology. This book provides a current review of the use of nitric oxide to treat pulmonary hypertension, whether idiopathic or secondary to congenital heart disease.
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