From Bench to Market
The Evolution of Chemical Synthesis
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From Bench to Market by Walter Cabri
Book DescriptionWho wins the race to turn molecules into medicines? How much does it cost? What factors influence the choice of synthetic routes and reaction mechanisms? How can pharmaceutical companies protect their discoveries? In From Bench to Market, Walter Cabri and Romano Di Fabio chart the process of industrial chemical synthesis, from the first discovery of a molecule, or 'new chemical entity', to its entry in the marketplace as a drug. They discuss all aspects related to the process research for bulk production, including comparison between different synthetic routes, key methodologies and reaction mechanisms, costs, patent competition, and crystalline forms. The authors use the real chemical history of the development of drugs from several therapeutic areas as detailed case studies, each chosen to illustrate a range of issues and methodologies in industrial chemistry. Several chapters cover the development of the various ss-lactam antibiotics; two chapters describe the discovery and synthesis of the anticancer drugs Idarubicin and Paclitaxal; in another chapter, the synthesis of the anti-viral drug Acyclovir and the 'patent war' that resulted are explored. Between them, the authors represent considerable first-hand experience in pharmaceutical research and development. The technical, practical, and strategic information they have amassed make this essential reading for graduate and undergraduate chemists intending to work in the pharmaceutical industry, as well as for industrial chemists themselves. Lecturers teaching courses in medicinal and organic chemistry will also find it useful.
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Book DetailsISBN: 9780198503842
(253mm x 194mm x 21mm)
Imprint: Oxford University Press
Publisher: Oxford University Press
Publish Date: 19-Oct-2000
Country of Publication: United Kingdom
Books By Author Walter Cabri
From Bench to Market, Paperback (October 2000)» View all books by Walter Cabri
The authors here chart the process of industrial chemical synthesis, from the first discovery of a molecule, or "new chemical entity", to its entry in the marketplace as a drug, with all the development needs and problems that take place along the way.
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Author Biography - Walter Cabri
Walter Cabri, R+D Director, Research and Development, Antibioticos, Rodano, Italy email@example.com Romano Di Fabio, Head of CNS Medicinal Chemistry, Medicines and Research Centre, Glaxo- Wellcome, Verona, Italy firstname.lastname@example.org
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