HPLC Method Development for Pharmaceuticals
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HPLC Method Development for Pharmaceuticals by Satinder Ahuja
Book DescriptionHigh pressure, or high performance, liquid chromatography (HPLC) is the method of choice for checking purity of new drug candidates, monitoring changes during scale up or revision of synthetic procedures, evaluating new formulations, and running control/assurance of the final drug product. "HPLC Method Development for Pharmaceuticals" provides an extensive overview of modern HPLC method development that addresses these unique concerns. It includes a review and update of the current state of the art and science of HPLC, including theory, modes of HPLC, column chemistry, retention mechanisms, chiral separations, modern instrumentation (including ultrahigh-pressure systems), and sample preparation. Emphasis has been placed on implementation in a pharmaceutical setting and on providing a practical perspective. "HPLC Method Development for Pharmaceuticals" is intended to be particularly useful for both novice and experienced HPLC method development chemists in the pharmaceutical industry and for managers who are seeking to update their knowledge. It covers the requirements for HPLC in a pharmaceutical setting including strategies for software and hardware validation to allow for use in a regulated laboratory. It provides an overview of the pharmaceutical development process (clinical phases, chemical and pharmaceutical development activities). It discusses how HPLC is used in each phase of pharmaceutical development and how methods are developed to support activities in each phase.
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Book DetailsISBN: 9780123705402
(240mm x 165mm x 28mm)
Imprint: Academic Press Inc
Publisher: Elsevier Science Publishing Co Inc
Publish Date: 15-May-2007
Country of Publication: United States
Books By Author Satinder Ahuja
Water Challenges and Solutions on a Global Scale, Hardback (September 2016)
This book provides information on various global water challenges and solutions by addressing scientific, technical, economic, and social issues.
Chemistry of Food, Food Production, and Food Contact Materials, Hardback (March 2016)View all books by Satinder Ahuja
Presents a comprehensive background of the chemistry behind the food system, from implementating new advancements, to food production, to national distribution.
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Author Biography - Satinder Ahuja
Satinder Ahuja earned his PhD in analytical chemistry from the University of the Sciences, Philadelphia. He worked for Novartis Corp. in various leadership positions for over 25 years while simultaneously teaching and guiding research as an adjunct professor at Pace University for over 10 years. As president of Ahuja Consulting, he advises on quality issues relating to chemicals/pharmaceuticals and water. Dr. Ahuja has published numerous papers and more than eighteen books. Two of his latest books are entitled "Water Reclamation and Sustainability" (Elsevier) and Comprehensive "Water Quality and Purification" (Elsevier). Others include "Monitoring Water Quality: Pollution Assessment, Analysis, and Remediation" (Elsevier, 2013); "Novel Solutions to Water Pollution" (ACS Symposium Volume, 2013); "Handbook of Water Purity and Quality" (Elsevier, 2009); and "Arsenic Contamination of Water: Mechanism, Analysis, and Remediation" (Wiley, 2008). A member of the executive committee of Rivers of the World Foundation (ROW), Dr. Ahuja is an expert on improving water quality and has organized numerous global symposia on this topic (American Chemical Society, UNESCO, etc.) In 2013, he gave a lecture on the nexus of food, energy, and water and chaired a symposium on the subject for the American Chemical Society meeting in New Orleans.
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