Innovative Drug Development for Headache Disorders
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Innovative Drug Development for Headache Disorders by Jes Olesen
Book DescriptionMigraine treatment improved considerably with the advent of the 'triptans' in the 1990s. While the drugs used previously for headache treatment had efficacy, some compounds had bothersome side effects and their overuse could lead to severe complications. In the early days of the triptans, it was widely presumed that migraine was no longer a treatment problem. However, it has gradually been recognized that a significant proportion of patients are not responsive to triptans or do not tolerate them. It is now clear that, even with effective treatment, patients with frequent migraine attacks are not treated well exclusively with acute medications. This is partly because patients are still bothered by the attacks and partly because frequent intake of acute medication may result in medication-overuse headache. These problems have led to a renewed interest in preventive migraine drugs. Part of the Frontiers in Headache Research series, this book summarizes the several promising new avenues for the development of future drugs for the treatment of migraine, including cortical-spreading depression inhibition, nitric oxide synthase inhibition and calcitonin gene-related peptide (CGRP) receptor antagonism, as well as other potential targets. The book presents frontline knowledge of these evolving modalities as far as it is available in the public domain. It is hoped that readers and their patients will find it exciting to learn about all the novel possibilities, and also that the impressive research advances in migraine will lead to increased funding, not only of migraine but also of other types of headache.
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Book DetailsISBN: 9780199552764
(254mm x 177mm x 18mm)
Imprint: Oxford University Press
Publisher: Oxford University Press
Publish Date: 21-Aug-2008
Country of Publication: United Kingdom
Books By Author Jes Olesen
Headache Care, Research and Education Worldwide, Hardback (May 2010)
This book brings the theme of a global campaign to the forefront. Researchers, scientists, and respected clinicians from around the world discuss aspects of access to care, individual and societal burden.
Headache Clinics, Hardback (March 2007)
There are few specialised headache centres throughout the world and those that do exist are often not developed enough to provide the services required. This book takes a look at the current situation examining the organisation of headache clinics, methods of diagnosis and treatment and how the future of headache clinics can be improved.
From Basic Pain Mechanisms to Headache, Hardback (February 2006)
Explores how the basic pain mechanisms relate to migraine and other forms of headache. This book is useful for clinicians treating headache sufferers, providing answers to the commonly asked questions about the mechanisms of their headache. It is also of interest to those pain researchers dealing with mechanisms related to headache and migraine.
Classification and Diagnosis of Headache Disorders, Hardback (March 2005)» View all books by Jes Olesen
Recently there has been a revised classification system (ICHD-2) which aims to aid diagnosis of headaches. This book discusses the background and implications of the classification system and clarifies the situation for clinicians and researchers.
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