Mental Retardation and Developmental Delay
Genetic and Epigenetic Factors
By (author) Moyra Smith
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Mental Retardation and Developmental Delay by Moyra Smith
Book DescriptionRecent advances in neuroscience and genetics have greatly expanded our understanding of the brain and of the etiological factors involved in developmental delay and mental retardation. At the same time, the human genome project has yielded a wealth of information on DNA sequencing, regulation of gene expression, epigenetics, and functional aspects of the genome, which newly propels investigation into the pathogenesis of mental retardation. This book makes readily available current knowledge on the subject and applies it to clinical medicine, providing information essential to neurologists, geneticists, physicians and pediatricians as they search for the causes of mental handicap in their patients. Introductory chapters cover normal and abnormal brain structure, neurogenesis, neuronal proliferation, and signal transduction. Latter chapters delve into discussions of both the environmental factors that may lead to neurocognitive deficits and the cytogenetic, biochemical and molecular defects specifically associated with mental retardation. One chapter reviews gene involvement in non-syndromic mental retardation, autism, and language deficits, as well as multifactorial and genetically complex inheritance. The text concludes with a clinically practical discussion of carrier detection, presymptomatic diagnosis, and treatment of various genetic diseases through enzyme therapy, substrate deprivation, and the use of hemapoietic stem cells.
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Book DetailsISBN: 9780195174328
(242mm x 162mm x 21mm)
Imprint: Oxford University Press Inc
Publisher: Oxford University Press Inc
Publish Date: 1-Dec-2005
Country of Publication: United States
Books By Author Moyra Smith
Seeking Cures, Hardback (September 2013)
Seeking Cures outlines the progress and implications of science's quest to identify therapeutic targets and initiate novel treatments at the gene, RNA, protein, and physiological levels. Also considered are aspects of treatment at the cellular level (e.g., those with hematopoietic stem cells or induced pluripotent stem cells).
Year in Human and Medical Genetics, 2009, Paperback (February 2009)View all books by Moyra Smith
This is the inaugural volume for a new annual review serving the medical genetics community. This annual volume will feature in-depth scholarly reviews of the most timely and important topics and issues affecting this field. NOTE: Annals volumes are available for sale as individual books or as a journal.
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