Meselson, Stahl and the Replication of DNA
A History of the Most Beautiful Experiment in Biology
By (author) Frederic Lawrence Holmes
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Meselson, Stahl and the Replication of DNA by Frederic Lawrence Holmes
Book DescriptionIn 1957 two young scientists, Matthew Meselson and Frank Stahl, produced a landmark experiment confirming that DNA replicates as predicted by the double helix structure Watson and Crick had recently proposed. It also gained immediate renown as a "most beautiful" experiment whose beauty was tied to its simplicity. Yet the investigative path that led to the experiment was anything but simple, Frederic L. Holmes shows in this masterful account of Meselson and Stahl's quest. This book vividly reconstructs the complex route that led to the Meselson-Stahl experiment and provides an inside view of day-to-day scientific research--its unpredictability, excitement, intellectual challenge, and serendipitous windfalls, as well as its frustrations, unexpected diversions away from original plans, and chronic uncertainty. Holmes uses research logs, experimental films, correspondence, and interviews with the participants to record the history of Meselson and Stahl's research, from their first thinking about the problem through the publication of their dramatic results. Holmes also reviews the scientific community's reception of the experiment, the experiment's influence on later investigations, and the reasons for its reputation as an exceptionally beautiful experiment.
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Book DetailsISBN: 9780300085402
(234mm x 156mm x 33mm)
Imprint: Yale University Press
Publisher: Yale University Press
Publish Date: 2-Jan-2002
Country of Publication: United States
Books By Author Frederic Lawrence Holmes
Investigative Pathways, Hardback (March 2004)
Holmes investigates scientific creativity, following the research pathways of outstanding scientists over the past three centuries, to find common features in their careers and their landmark discoveries, and shed light on the nature of long-term experimental research.
Hans Krebs, Hardback (April 1993)» View all books by Frederic Lawrence Holmes
This second and final volume of the biography of Hans Krebs covers his early years in England, 1933-1937, when he laid the foundations of our modern understanding of intermediary metabolism.
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