Molecular Chaperones and Cell Signalling by Brian Henderson
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Molecular Chaperones and Cell Signalling
By Brian Henderson

Molecular Chaperones and Cell Signalling

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Format: Hardback

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Molecular Chaperones and Cell Signalling by Brian Henderson

Book Description

This book reviews understanding of the biological roles of extracellular molecular chaperones. It provides an overview of the structure and function of molecular chaperones, their role in the cellular response to stress and their disposition within the cell. It also questions the basic paradigm of molecular chaperone biology - that these proteins are first and foremost protein-folding molecules. Paradigms of protein secretion are reviewed and the evolving concept of proteins (such as molecular chaperones) as multi-functional molecules for which the term 'moonlighting proteins' has been introduced is discussed. The role of exogenous molecular chaperones as cell regulators is examined and the physiological and pathophysiological role that molecular chaperones play is described. In the final section, the potential therapeutic use of molecular chaperones is described and the final chapter asks the question - what does the future hold for the extracellular biology of molecular chaperones?

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Book Details

ISBN: 9780521836548
ISBN-10: 0521836549
Format: Hardback
(228mm x 152mm x 24mm)
Pages: 346
Imprint: Cambridge University Press
Publisher: Cambridge University Press
Publish Date: 18-Jul-2005
Country of Publication: United Kingdom

Other Editions...


Books By Author Brian Henderson

Protein Moonlighting in Biology and Medicine by Brian Henderson Protein Moonlighting in Biology and Medicine, Hardback (December 2016)

The past 25 years has seen the emergence of a wealth of data suggesting that novel biological functions of known proteins play important roles in biology and medicine. This ability of proteins to exhibit more than one unique biological activity is known as protein moonlighting.

Human Microbiota and Chronic Disease by Brian Henderson Human Microbiota and Chronic Disease, Hardback (September 2016)

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[Or] by Brian Henderson [Or], Paperback (January 2015)

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Molecular Chaperones and Cell Signalling by Brian Henderson Molecular Chaperones and Cell Signalling, Paperback (March 2011)

This text reviews understanding of the biological roles of extracellular molecular chaperones.

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Author Biography - Brian Henderson

Brian Henderson is Professor of Cell Biology at the Eastman Dental Institute, University College London and head of the Cellular Microbiology Research Group. He is the coauthor of Bacterial Disease Mechanisms (2002) and the coeditor of Bacterial Evasion of Host Immune Responses (2003). His major research interests are concerned with bacterial interactions with the host and how such interactions control inflammation and associated tissue destruction. It is through these studies that he identified that molecular chaperones are bacterial virulence factors and started his interest in the direct immunomodulatory actions of cell stress proteins. A. Graham Pockley is Professor of Immunobiology at the University of Sheffield Medical School and is head of the Immunobiology Research Unit. Professor Pockley has long-standing interests in the immunobiology of transplant rejection and his Unit is currently focussed on research relating to the biology and immunotherapeutic potential of heat shock proteins, particularly their involvement in the rejection of organ transplants and the development and progression of cardiovascular disease.

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