Nicotinic Acetylcholine Receptors
From Molecular Biology to Cognition
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Nicotinic Acetylcholine Receptors by Jean-Pierre Changeux
Book DescriptionThe acetylcholine nicotinic receptor is among the most studied receptors in neuroscience. Involved in muscle contraction and a wide variety of other neurological functions, including the processing of nicotine, it was the first receptor to be isolated and observed at the molecular level, providing a major research pathway for scientists working in neuroscience, biochemistry, pharmacology, and behavioral science. This book describes four decades of scientific research that inform our current understanding of this receptor. Jean-Pierre Changeux and Stuart J. Edelstein played important roles in pioneering research on the acetylcholine nicotinic receptor and on allosteric proteins, and here they reveal the complete scientific trajectory of that research. They begin with a historical perspective, describing how several fields converged around a single receptor and then explain the initial receptor purification and characterization. Subsequent chapters trace the investigations into various aspects of receptor structure and function, including the chemical structure of the binding site, the identity and properties of the ion channel, and the mechanism of signal transmission. In the final portion of the book, Changeux and Edelstein discuss recent studies on the three-dimensional structure of the receptor molecule and share their novel understanding of inherited diseases such as congenital myasthenia and epilepsy. They also address the integration of the receptor into its synaptic membrane environment and its distribution, physiology, and regulation in brain functions and cognition. Richly illustrated and lucidly written, this book provides an exceptional opportunity for scientists and students to follow a historic advance in our knowledge of molecular mechanisms and the workings of the brain.
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Book DetailsISBN: 9780976890805
(235mm x 178mm x 22mm)
Imprint: Odile Jacob
Publisher: Johns Hopkins University Press
Publish Date: 1-Nov-2005
Country of Publication: United States
Books By Author Jean-Pierre Changeux
Good, the True, and the Beautiful, Hardback (May 2012)
An eminent neurobiologist reflects on the human brain, connecting recent scientific findings with ideas from an array of other disciplines
Physiology of Truth, Paperback (March 2009)
Drawing on provocative findings about the psychophysiology of perception and judgment in both human and nonhuman primates, and also on the cultural history of science, this title makes a case for the reality of scientific progress and argues that it forms the basis for a coherent and universal theory of human rights.
What Makes Us Think?, Paperback (February 2002)
Will understanding our brains help us to know our minds? Or is there an unbridgeable distance between the work of neuroscience and the workings of human consciousness? This book explores the vexed territory between these divergent approaches - and comes to a deeper, more complex perspective on human nature.
Origins of the Human Brain, Paperback (July 1996)» View all books by Jean-Pierre Changeux
This work presents the views of a group of scientists from the fields of anthropology, psychology, neuroscience, and evolutionary biology, to provide a starting point for a debate based on the most recent scientific data relating to the evolutionary origins of the human brain.
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Author Biography - Jean-Pierre Changeux
Jean-Pierre Changeux is a professor at the College de France and at the Institut Pasteur, where he is also director of the receptors and cognitions unit. Stuart J. Edelstein is a professor of biochemistry at the University of Geneva.
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