Nucleic Acid Structure and Recognition
By (author) Stephen Neidle
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Nucleic Acid Structure and Recognition by Stephen Neidle
Book DescriptionThis book provides a detailed view of the molecular structures of DNA and RNA and how they are recognised by small molecules and proteins. Extensive source material is provided, including information on relevant web sites and computer programmes. The major methods of structural investigation for nucleic acids: X-ray crystallography, NMR, and molecular modelling are reviewed and their scope and limitations (in the context of nucleic acids) discussed. Also covered are the conformational features of nucleic acid building blocks, including a description of how base-pair morphologies are analysed; the structures of DNA double helices and helical oligonucleotides, emphasising current ideas on sequence-dependent structure; and DNA-DNA interactions, including triplexes and quadruplexes. The principles of RNA folding, ribosome, and ribozyme structure are also surveyed. Both covalent and non-covalent nucleic acid interactions with small molecules are described, with the emphasis on recognition principles and sequence specific gene recognition. The principles of protein - nucleic acid are covered, focussing on regulatory proteins. Nucleic Acid Structure and Recognition will therefore equip readers with a good understanding of all the important aspects of this major field. The Nucleic Acid Database (NDB) crystallographic and NMR structures for the nucleic acid structures described in the book are freely available through the Nucleic Acid Structure and Recognition website.
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Book DetailsISBN: 9780198506355
(239mm x 169mm x 12mm)
Imprint: Oxford University Press
Publisher: Oxford University Press
Publish Date: 30-May-2002
Country of Publication: United Kingdom
Books By Author Stephen Neidle
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Focuses on the underlying principles for the design and subsequent development of new anticancer small molecule agents. This book includes several sections on the basic and applied science of cancer drug discovery and features those drugs that are approved for human use and are in the marketplace, as well as those that are still under development.
Principles of Nucleic Acid Structure, Paperback (November 2007)
Provides a summary of underlying principles and approaches to studying nucleic acid structure, including discussion of x-ray crystallography, NMR, molecular modelling, and databases. This book focusses on a survey of structures important for biomedical research and pharmacological applications.
Oxford Handbook of Nucleic Acid Structure, Hardback (March 1999)» View all books by Stephen Neidle
This is an up-to-date and comprehensive reference handbook of all aspects of nucleic acid structure, with particular emphasis on the results from X-ray crystallography and NMR studies. The contributors are authorities in their fields, and provide balanced surveys which cover underlying fundamentals as well as recent advances.
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