Randomization in Clinical Trials by William F. Rosenberger
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Randomization in Clinical Trials
By William F. Rosenberger

Randomization in Clinical Trials

Theory and Practice

By (author) See other recent books by William F. Rosenberger See other recent books by John M. Lachin
Format: Hardback

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Randomization in Clinical Trials by William F. Rosenberger

Book Description

A unique overview that melds the concepts of conditional probability and stochastic processes into real-life applications The role of randomization techniques in clinical trials has become increasingly important. This comprehensive guide combines both the applied aspects of randomization in clinical trials with a probabilistic treatment of properties of randomization. Taking an unabashedly non-Bayesian and nonparametric approach to inference, the book focuses on the linear rank test under a randomization model, with added discussion on likelihood-based inference as it relates to sufficiency and ancillarity. Developments in stochastic processes and applied probability are also given where appropriate. Intuition is stressed over mathematics, but not without a clear development of the latter in the context of the former. Providing a consolidated review of the field, the book includes relevant and practical discussions of: The benefits of randomization in terms of reduction of bias Randomization as a basis for inference Covariate-adaptive and response-adaptive randomization Current philosophies, controversies, and new developments With ample problem sets, theoretical exercises, and short computer simulations using SAS, Randomization in Clinical Trials: Theory and Practice is equally useful as a standard textbook in biostatistics graduate programs as well as a reliable reference for biostatisticians in practice.

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Book Details

ISBN: 9780471236269
ISBN-10: 0471236268
Format: Hardback
(243mm x 168mm x 22mm)
Pages: 288
Imprint: John Wiley & Sons Inc
Publisher: John Wiley and Sons Ltd
Publish Date: 30-Jul-2002
Country of Publication: United States

Other Editions...


Books By Author William F. Rosenberger

Randomization in Clinical Trials by William F. Rosenberger Randomization in Clinical Trials, Hardback (January 2016)

This Second Edition features a unique overview that melds the concepts of conditional probability and stochastic processes into real-life applications.

Theory of Response-Adaptive Randomization in Clinical Trials by William F. Rosenberger Theory of Response-Adaptive Randomization in Clinical Trials, Hardback (September 2006)

In this well written book, the authors treat the fundamental question of response-adaptive randomization as dealing with the trade-off between minimizing the expected number of treatment failures and maximizing the power of inferential tests.

» View all books by William F. Rosenberger

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Author Biography - William F. Rosenberger

WILLIAM F. ROSENBERGER is an associate professor (with tenure) of mathematics and statistics at The University of Maryland, Baltimore County. He is also an adjunct associate professor of epidemiology and preventive medicine at the University of Maryland School of Medicine. He serves as a biostatistical consultant on several clinical trials data and safety monitoring boards for the NIH, VA, and industry. He received his PhD in mathematical statistics from The George Washington University. JOHN M. LACHIN III is presently Professor of Biostatistics and Epidemiology, and of Statistics, at The George Washington University. He holds a ScD in biostatistics from the University of Pittsburgh. He also serves as Director of the Graduate Program in Biostatistics and as Director of the Coordinating Center for two nationwide studies in diabetes.

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