Regulators and Effectors of Small GTPases
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Regulators and Effectors of Small GTPases by W. E. Balch
Book DescriptionThe Ras superfamily (>150 human members) encompasses Ras GTPases involved in cell proliferation, Rho GTPases involved in regulating the cytoskeleton, Rab GTPases involved in membrane targeting/fusion and a group of GTPases including Sar1, Arf, Arl and dynamin involved in vesicle budding/fission. These GTPases act as molecular switches and their activities are controlled by a large number of regulatory molecules that affect either GTP loading (guanine nucleotide exchange factors or GEFs) or GTP hydrolysis (GTPase activating proteins or GAPs). In their active state, they interact with a continually increasing, functionally complex array of downstream effectors. Since the last Methods in Enzymology volume on this topic in 2000, the study of Ras Family GTPases has witnessed a plethora of new directions and trends. With regards to the founding member of the Ras superfamily, the study of Ras in oncogenesis has seen the development and application of more advanced model cell culture and animal systems. The discovery of mutationally activated B-Raf in human cancers has injected renewed interest in this classical effector pathway of Ras.
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Book DetailsISBN: 9780121828127
(229mm x 152mm x 34mm)
Imprint: Academic Press Inc
Publisher: Elsevier Science Publishing Co Inc
Publish Date: 7-Jun-2006
Country of Publication: United States
Books By Author W. E. Balch
Small GTPases in Disease, Hardback (June 2008)
Focusing on the field of biochemistry, this title is suitable for researchers in the field of life sciences. It covers the topic of small GTPases and their role in disease.
Regulators and Effectors of Small GTPases, Hardback (February 2006)» View all books by W. E. Balch
Describes some of the methods used to examine Rho family GTPase regulation at the biochemical and cellular level. This volume includes imaging techniques that revolutionize the ability to visualize GTPase activities.
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