Functional Genomics to Gene Therapy
By (author) Novartis Foundation
Normal Price: $315.95
Your Price: $284.36 AUD, inc. GST
Shipping: $7.95 per order
You Save: $31.59! (10% off normal price)
Plus...earn $14.22 in Boomerang Bucks
Availability: Available to Backorder, No Due Date for Supply
Retinal Dystrophies by Novartis Foundation
Book DescriptionRetinal dystrophies are the major causes of incurable blindness in the Western world. Our insight into their aetiology has improved remarkably over the past decade and a number of key genes have been identified. Together with a more detailed understanding of disease processes, this knowledge is stimulating new approaches to therapeutic strategies involving gene therapy, growth factors and retinal cell transplantation. Molecular genetic studies have provided detailed information on the pathogenesis of retinal dystrophies. An important proof of principle that gene therapy holds great promise for the treatment of these conditions was demonstrated in the rds mouse: introduction of a functional copy of the peripherin gene subretinally resulted in complete rescue of rod outer segment structure. Novel approaches are being developed based on the manipulation of biochemical pathways that previously were not considered relevant to these diseases. For example, renewed interest in retinal dystrophy pathogenesis led to the successful use of high dose vitamin A treatment in Sorsby fundus dystrophy. This important new book covers all aspects of retinal dystrophies from the molecular and developmental biology of these disorders to possible therapeutic approaches, with special reference to gene therapy. Specific chapters deal with the molecular genetics of gene therapies, clinical genetic studies, molecular and cellular mechanisms of the development of the disease, functional genomics of retinal diseases, animal models of retinal dystrophies, and finally with studies on gene therapeutic approaches to correcting the disorder. With contributions by many of the leading researchers worldwide, this book is likely to be an important milestone in this rapidly developing field.
Buy Retinal Dystrophies book by Novartis Foundation from Australia's Online Bookstore, Boomerang Books.
Book DetailsISBN: 9780470853573
(237mm x 165mm x 16mm)
Imprint: John Wiley & Sons Ltd
Publisher: John Wiley and Sons Ltd
Publish Date: 5-Dec-2003
Country of Publication: United Kingdom
Books By Author Novartis Foundation
Defining Optimal Immunotherapies for Type 1 Diabetes, Hardback (June 2008)
* This book is a comprehensive and up-to-date account of where we stand in immunological strategies for preventing or treating type 1 diabetes (T1D).
Novel and Re-emerging Respiratory Viral Diseases, Hardback (April 2008)
The past decade has seen mounting global concern regarding viral outbreaks such as SARS, avian influenza and West Nile virus. In 2004 and 2005, reports of bird-to-human, and possible human-to-human, transmissions of the H5N1 influenza viruses raised fears that these viruses could cause a pandemic on the scale of the Spanish flu pandemic of 1918.
Biology of Extracellular Molecular Chaperones, Hardback (March 2008)
The heat shock, or cell stress, response was first identified in the polytene chromosomes of Drosophila. This was later related to the appearance of novel proteins within stressed cells, and the key signal stimulating this appearance was identified as the presence of unfolded proteins within the cell.
Growth Factors and Psychiatric Disorders, Hardback (February 2008)» View all books by Novartis Foundation
The recent identification of susceptibility genes for schizophrenia, depression and learning and memory dysfunction suggest that psychiatric disorders may be influenced by a small number of genes with multiple actions.
» Have you read this book? We'd like to know what you think about it - write a review about Retinal Dystrophies book by Novartis Foundation and you'll earn 50c in Boomerang Bucks loyalty dollars (you must be a member - it's free to sign up!)
Phone: 1300 36 33 32 (9am-5pm Mon-Fri AEST) - International: +61 2 9960 7998 - Online Form
Address: Boomerang Books, 878 Military Road, Mosman Junction, NSW, 2088
© 2003-2017. All Rights Reserved. Eclipse Commerce Pty Ltd - ACN: 122 110 687 - ABN: 49 122 110 687