Reverse Engineering Biological Networks by Gustavo Stolovitzky
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Reverse Engineering Biological Networks
By Gustavo Stolovitzky

Reverse Engineering Biological Networks

Opportunities and Challenges in Computational Methods for Pathway Inference

Edited by See other recent books by Gustavo Stolovitzky See other recent books by Andrea Califano
Format: Paperback

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Reverse Engineering Biological Networks by Gustavo Stolovitzky

Book Description

Computational biologists are striving to "reverse engineer" the underlying networks of interactions between the molecules in the cell. This volume and the conference it reports on attempt a systematic evaluation of reverse engineering methods. The DREAM project brings together a diverse group of researchers to clarify potentials and limitations of the enterprise of reverse engineering cellular networks. An important aspiration of the project is to compare the effectiveness of different methods in reverse engineering biological networks. Evaluating this requires a "gold standard" network for which at least the true topology of connections is known. Many participants, especially the computational biologists, believe that synthetic networks are good candidates for this purpose because, at least for now, only they can be described with certainty. Experimental biologists, however, worry that unless the project addresses real biological networks, it could evolve into a mathematical exercise with little impact on biology. These and other ideas are discussed. NOTE: Annals volumes are available for sale as individual books or as a journal. For information on institutional journal subscriptions, please visit www.blackwellpublishing.com/nyas. ACADEMY MEMBERS: Please contact the New York Academy of Sciences directly to place your order (www.nyas.org). Members of the New York Academy of Science receive full-text access to the Annals online and discounts on print volumes. Please visit http://www.nyas.org/MemberCenter/Join.aspx for more information about becoming a member

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Book Details

ISBN: 9781573316897
ISBN-10: 157331689X
Format: Paperback
(226mm x 155mm x 13mm)
Pages: 452
Imprint: New York Academy of Sciences
Publisher: New York Academy of Sciences
Publish Date: 18-Dec-2007
Country of Publication: United States

Books By Author Gustavo Stolovitzky

Challenges of Systems Biology by Gustavo Stolovitzky Challenges of Systems Biology, Paperback (June 2009)

At a microscopic level, organisms are ruled by interacting systems of biomolecules. Historically, scientists painstakingly elucidated chains of molecular events using experiments that reveal individual interactions, although they recognized that members of different pathways frequently interact.

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