The Role of Organic Synthesis in Early Clinical Drug Development
From Synthesis Design to Formulation
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Role of Organic Synthesis in Early Clinical Drug Development by Ahmed F. Abdel-Magid
Book DescriptionAn informative look at the intricacies of today's drug development process Once a discovery organization has identified a potential new drug candidate, it is the daunting task of synthetic organic chemists to identify the chemical process suitable for preparation of this compound in a highly regulated environment. Only through a multi-layered chemical process that takes into account such factors as safety, environmental considerations, freedom to operate and cost-effectiveness can researchers begin to refine the drug in terms of quality and yield. This book covers both recent advances in the design and synthesis of new drugs, as well as the myriad other issues facing a new drug candidate as it moves through the development process. Utilizing recent case studies, the authors provide valuable insights into the complexities of the process, from designing new synthetic methodologies and applying new automated techniques for finding optimal reaction conditions to selecting the final drug form and formulation. Both novice and active researchers will appreciate the inclusion of chapters on such diverse topics as: Cross-coupling methods Asymmetric synthesis Automation Chemical Engineering Application of radioisotopes Final form selection Formulations Intellectual property A wealth of real-world examples and contributions from leading process scientists, engineers, and related professionals make this book a valuable addition to the scientific literature.
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Book DetailsISBN: 9780471692782
(234mm x 162mm x 22mm)
Imprint: John Wiley & Sons Inc
Publisher: John Wiley and Sons Ltd
Publish Date: 3-Oct-2006
Country of Publication: United States
Books By Author Ahmed F. Abdel-Magid
Managing Hazardous Reactions and Compounds in Process Chemistry, Hardback (August 2015)» View all books by Ahmed F. Abdel-Magid
This book provides an informative overview of chemical reaction safety and managing hazards associated with carrying out chemical reactions.
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Author Biography - Ahmed F. Abdel-Magid
AHMED F. ABDEL-MAGID is a Senior Research Fellow in Chemical and Pharmaceutical Development at Johnson & Johnson Pharmaceutical Research & Development, L.L.C. STEPHANE CARON is a Director in Chemical Research and Development at Pfizer Global R&D.
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