Sample Sizes for Clinical Trials
By (author) Steven A. Julious
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Sample Sizes for Clinical Trials by Steven A. Julious
Book DescriptionDrawing on various real-world applications, Sample Sizes for Clinical Trials takes readers through the process of calculating sample sizes for many types of clinical trials. It provides descriptions of the calculations with a practical emphasis. Focusing on normal, binary, ordinal, and survival data, the book explores a range of trials, including superiority, equivalence, non-inferiority, bioequivalence, and precision for both parallel group and crossover designs. The author discusses how trial objectives impact the study design with respect to the derivation of formulae for sample size calculations. He uses real-life studies throughout to show how the concepts and calculations can be employed. This work underscores the importance of sample size calculation in the design of a clinical trial. With useful calculation tables throughout, it enables readers to quickly find an appropriate formula, formula application, and associated worked example. Watch the author speak about this book at JSM 2012 in San Diego.
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Book DetailsISBN: 9781584887393
(235mm x 156mm x 23mm)
Imprint: Chapman & Hall/CRC
Publisher: Taylor & Francis Ltd
Publish Date: 4-Aug-2009
Country of Publication: United States
Books By Author Steven A. Julious
Introduction to Statistics in Early Phase Trials, Hardback (March 2010)
This guide offers an overview of the most common types of trial undertaken in early clinical development. The coverage discusses the different methodologies and the impact of new technologies, both clinical and statistical, on clinical development.
Sample Size Tables for Clinical Studies, Hardback (November 2008)» View all books by Steven A. Julious
This book provides statisticians and researchers with the statistical tools - equations, formulae, and numerical tables - to design and plan clinical studies and carry out accurate, reliable, and reproducible analysis of the data so obtained.
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Author Biography - Steven A. Julious
Steven A. Julious is a Senior Lecturer in Medical Statistics at the University of Sheffield. His research interests include clinical trials, clinical trial design, early phase trials, and the development of new methodologies related to clinical trials.
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