Statistical Mechanics and Stability of Macromolecules
Application to Bond Disruption, Base Pair Separation, Melting, and Drug Dissociation of the DNA Double Helix
By (author) Earl Prohofsky
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Statistical Mechanics and Stability of Macromolecules by Earl Prohofsky
Book DescriptionThis book develops a statistical mechanical analysis of the stability of biological macromolecules. The author's approach is valid both for the long time-scale needed for DNA bond disruption, and also for highly co-operative transitions needed to explain helix melting. A new theoretical approach for executing macromolecule calculations is developed. In particular, the author devises a method for describing chemical bond disruption in these large systems, which are then used to determine when the helix melts and how drugs can dissociate from the helix. Melting temperatures are found to be in excellent agreement with experimental observations. The book will be of interest to biomolecular dynamics researchers, especially to graduate students in biological physics, theoretical chemistry and molecular biology.
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Book DetailsISBN: 9780521451840
(228mm x 152mm x 14mm)
Imprint: Cambridge University Press
Publisher: Cambridge University Press
Publish Date: 28-Jul-1995
Country of Publication: United Kingdom
Books By Author Earl Prohofsky
Statistical Mechanics and Stability of Macromolecules, Paperback (July 2005)» View all books by Earl Prohofsky
This book develops a statistical, mechanical analysis of the stability of macromolecules when melting.
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