Statistical Mechanics and Stability of Macromolecules by Earl Prohofsky
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Statistical Mechanics and Stability of Macromolecules
By Earl Prohofsky

Statistical Mechanics and Stability of Macromolecules

Application to Bond Disruption, Base Pair Separation, Melting, and Drug Dissociation of the DNA Double Helix

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Format: Paperback

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Statistical Mechanics and Stability of Macromolecules by Earl Prohofsky

Book Description

This book develops a statistical mechanical analysis of the stability of biological macromolecules. The author's approach is valid both for the long time-scale needed for DNA bond disruption, and also for highly co-operative transitions needed to explain helix melting. A new theoretical approach for executing macromolecule calculations is developed. In particular, the author devises a method for describing chemical bond disruption in these large systems, which are then used to determine when the helix melts and how drugs can dissociate from the helix. Melting temperatures are found to be in excellent agreement with experimental observations. The book will be of interest to biomolecular dynamics researchers, especially to graduate students in biological physics, theoretical chemistry and molecular biology.

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Book Details

ISBN: 9780521675574
ISBN-10: 052167557X
Format: Paperback
(228mm x 152mm x 13mm)
Pages: 240
Imprint: Cambridge University Press
Publisher: Cambridge University Press
Publish Date: 14-Jul-2005
Country of Publication: United Kingdom

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Books By Author Earl Prohofsky

Statistical Mechanics and Stability of Macromolecules by Earl Prohofsky Statistical Mechanics and Stability of Macromolecules, Hardback (July 1995)

This book develops a statistical, mechanical analysis of the stability of macromolecules when melting.

» View all books by Earl Prohofsky

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