Edited by Hugh Markus
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Stroke Genetics by Hugh Markus
Book DescriptionStroke is a major cause of death and the major cause of adult neurological disability in most of the world. Despite its importance on a population basis, research into the genetics of stroke has lagged behind that of many other disorders. However, the situation is now changing. An increasing number of single gene disorders causing stroke are being described, and there is growing evidence that polygenic factors are important in the risk of apparently "sporadic" stroke. Stroke Genetics provides an up-to-date review of the area, suitable for clinicians treating stroke patients, and both clinical and non-clinical researchers in the field of cerebrovascular disease. The full range of monogenic stroke disorders causing cerebrovascular disease, including ischaemic stroke, intracerebral haemorrhage, aneurysms and arteriovenous malformations, are covered. For each, clinical features, diagnosis, and genetics are described. Increasing evidence suggest that genetic factors are also important for the much more common multifactorial stroke; this evidence is reviewed along with the results of genetic studies in this area. Optimal and novel strategies for investigating multifactorial stroke, including the use of intermediate phenotypes such as intima-media thickness and MRI detected small vessel disease are reviewed. The book concludes by describing a practical approach to investigating patients with stroke for underlying genetic disorders. Also included is a list of useful websites.
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Book DetailsISBN: 9780198515869
(248mm x 174mm x 24mm)
Imprint: Oxford University Press
Publisher: Oxford University Press
Publish Date: 1-May-2003
Country of Publication: United Kingdom
Books By Author Hugh Markus
Stroke Medicine, Paperback (December 2016)» View all books by Hugh Markus
This book incorporates considerable advances in the treatment of stroke that have occurred since the first edition published. This provides an up-to-date and easily accessible source of information on all aspects of stroke care, from acute care through to rehabilitation and secondary prevention.
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