Toxicology of Organophosphate and Carbamate Compounds
Edited by Ramesh C. Gupta
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Toxicology of Organophosphate and Carbamate Compounds by Ramesh C. Gupta
Book DescriptionThis text/reference book provides the most comprehensive coverage of anticholinesterase compounds (Organophosphates and Carbamates), which constitute the largest number of chemicals that are primarily used as insecticides in agriculture, industry, and around the home/garden. Some OPs (nerve agents) have been used in chemical warfare and terrorist attacks, while some OPs and CMs have been recommended as therapeutic agents in human medicine as well as in veterinary medicine. Many chemicals of both classes are extremely toxic and lack selectivity, thus their inadvertent/accidental use continues to pose a threat to human and animal health, aquatic systems and wildlife. These anticholinesterase agents produce a variety of toxicological effects in target and nontarget organs. In light of this complexicity, this multi-authored book is written by the well known scientists from many countries. The book is organized into nine sections, with a total of 49 chapters, to provide in-depth knowledge on various aspects of OP and CM compounds, including their use, classification, mechanism-based toxicity, and prophylactic and therapeutic measurements. Several chapters are written with special emphasis to cover timely topics, such as chemical warfare agents, physiologically-based pharmacokinetic modeling, structure and function of cholinesterases, paraoxonase, carboxylesterases; developmental neurotoxicity, the intermediate syndrome, oxidative stress, endocrine disruption, and DNA damage/gene expression and carcinogenesis. Section-VI with 5 chapters is specifically devoted to risk assessment, and safety and regulatory guidelines for pesticides. * Describes everything you need to know about Organophosphates and Carbamates* Extensively covers pesticides, nerve agents, therapeutic drugs, and flame retardants* Describes epidemiology of the world's major disasters involving Organophosphates and Carbamates* Covers animal, human, aquatic, and wildlife toxicity of Anticholinesterases* Insights into in-depth cholinergic and noncholinergic mechanisms of toxicity* Describes recent advancements in cholinesterases, paraoxonases, carboxylesterases, oxidative stress, endocrine disruption, cardiac and pulmonary toxicity, and carcinogenesis* Provides in vitro and in vivo models for neurotoxicity testing* Integrates knowledge of studies in lab animals and humans* Offers risk/safety assessment and national/international guidelines for permissible levels of pesticide residues* Describes management of Anticholinesterase poisoning in humans
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Book DetailsISBN: 9780120885237
(279mm x 216mm x 40mm)
Imprint: Academic Press Inc
Publisher: Elsevier Science Publishing Co Inc
Publish Date: 20-Dec-2005
Country of Publication: United States
Books By Author Ramesh C. Gupta
Biomarkers in Toxicology, Hardback (April 2014)
Includes both vertebrate and non-vertebrate species models for toxicological testing and development of biomarkers. Divided into several key sections, this volume contains chapters devoted to topics in molecular-cellular toxicology, as well as a look at the technologies used to detect biomarkers of exposure and effects.
Veterinary Toxicology, Hardback (April 2012)
Suitable for practicing veterinary toxicologists, poison control centers, marine biologists, environmentalists, and animal scientists, this title teaches the basic principles of veterinary toxicology to any student at the DVM, MS or PhD level. It covers organ toxicity, radiation and radioactive materials, and ethics in veterinary toxicology.
Reproductive and Developmental Toxicology, Hardback (April 2011)» View all books by Ramesh C. Gupta
Reproductive toxicology is a complex subject dealing with three components-parent, placenta, and fetus-and the continuous changes that occur in each. This book addresses topics including nanoparticles and radiation, gases and solvents, smoking, alcohol and drugs of abuse, food additives, nutraceuticals and pharmaceuticals, metals, and more.
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Author Biography - Ramesh C. Gupta
Dr. Ramesh C. Gupta, Professor & Head of Toxicology Department at Murray State university, is engaged in experimental brain research in relation to Alzheimer(s) disease (AD) and pesticide toxicity. He has delivered lectures in Australia, Italy, Japan, Germany, France, Switzerland, Spain, Czech Republic, China, South Korea, and Sweden. He served the panels of NIH, CDC, NIOSH, and NAS. He has >350 publications to his credit, including six major books: (1) Toxicology of Organophosphate and Carbamate Compounds, (2) Veterinary Toxicology: Basic and Clinical Principles, (3) Handbook of Toxicology of Chemical Warfare Agents, (4) Anticholinesterase Pesticides: Metabolism, Neurotoxicity, and Epidemiology, (5) Reproductive and Developmental Toxicology, and (6) Biomarkers in Toxicology. He is recipient of Murray State University's distinguished researcher award of the year-2006. He is a diplomate of American Board of Toxicology, and fellow of American College of Toxicology, American College of Nutrition, and Academy of Toxicological Sciences.
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