Mathematical Principles of Immunology and Virology
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Virus Dynamics by Martin A. Nowak
Book DescriptionWe know, down to the tiniest details, the molecular structure of the human immunodeficiency virus (HIV). Yet despite this tremendous accomplishment, and despite other remarkable advances in our understanding of individual viruses and cells of the immune system, we still have no agreed understanding of the ultimate course and variability of the pathogenesis of AIDS. Gaps in our understanding like these impede our efforts towards developing effective therapies and preventive vaccines. Martin Nowak and Robert M May describe the emerging field of theoretical immunology in this accessible and well- written text. Using mathematical modelling techniques, the authors set out their ideas about how populations of viruses and populations of immune system cells may interact in various circumstances, and how infectious diseases spread within patients. They explain how this approach to understanding infectious diseases can reveal insights into the dynamics of viral and other infections, and the interactions between infectious agents and immune responses. The book is structured around the examples of HIV/AIDS and Hepatitis B virus, although the approaches described will be more widely applicable. The authors use mathematical tools to uncover the detailed dynamics of the infection and the effects of antiviral therapy. Models are developed to describe the emergence of drug resistance, and the dynamics of immune responses, viral evolution, and mutation. The practical implications of this work for optimisation of the design of therapy and vaccines are discussed. The book concludes with a glance towards the future of this fascinating, and potentially highly useful, field of study.
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Book DetailsISBN: 9780198504177
(235mm x 156mm x 14mm)
Imprint: Oxford University Press
Publisher: Oxford University Press
Publish Date: 23-Nov-2000
Country of Publication: United Kingdom
Books By Author Martin A. Nowak
Evolution, Games, and God, Hardback (May 2013)
Evolution, Games, and God explores how cooperation and altruism, alongside mutation and natural selection, play a critical role in evolution, from microbes to human societies. Inheriting a tendency to cooperate and self-sacrifice on behalf of others may be as beneficial to a population's survival as the self-preserving instincts of individuals.
Evolutionary Dynamics, Hardback (September 2006)» View all books by Martin A. Nowak
Evolutionary change is the consequence of mutation and natural selection, two concepts that can be described by mathematical equations. Introducing readers to the laws that govern the evolution of living systems, this book draws on the languages of biology and mathematics to outline the mathematical principles according to which life evolves.
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