Colin Royse, MBBS, MD, FANZCA. Cardiothoracic Anaesthetist, Royal Melbourne Hospital; Associate Professor and co-head of the Human Cardiovascular Research Laboratory, Department of Pharmacology, Melbourne University, Victoria, Australia. Garry Donnan, MBBS, FANZCA. Staff Anaesthetist, Department of Anaesthesia and Pain Management, the Royal Melbourne Hospital, Victoria, Australia. Alistair Royce, MBBS, MD, FRACS. Cardiothoracic surgeon, Royal Melbourne and Western Hospitals, Victoria, Australia; Associate Professor, Department of Pharmacology, Melbourne University, Victoria, Australia.