The Motoneurone and its Muscle Fibres presents a state-of-the-art summary of knowledge concerning the motoneurones, vital for innervating and commanding skeletal muscles. No muscle action would be possible without motoneurones. These cells are therefore absolutely essential for the execution of normal behaviour and for life support. It is their degeneration that leads to various kinds of motoneurone disease (e.g. ALS) that are often ultimately lethal. However, the study of motoneurones is also important for general insights as to how neurones work, because the motoneurone is probably the best understood kind of nerve cell so far in neuroscience. Motoneurones of the spinal cord were the first type of central nerve cell to be subjected to detailed physiological measurements, and much is known about how their activity is regulated by synapses from other central neurones. For most of the individual neurones within the central nervous system, the precise functional tasks are difficult to define. However, for motoneurones much is now known about their short- and long-term interactions with their main targets, the skeletal muscle fibres.
Functions of neurones must be analyzed in relation to the response properties of their target cells. Therefore, this book deals with both, summarizing classical as well as recent knowledge concerning the motoneurone and its muscle fibres. This is the first time that so many aspects of this broad subject matter are treated in one comprehensive monograph.
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(252mm x 175mm x 22mm)
Oxford University Press
Publisher: Oxford University Press
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Author Biography - Daniel Kernell
Daniel Kernell grew up in Stockholm and studied medicine at the Karolinska Institutet. From 1961-1972 he was associated with the Nobel Institute for Neurophysiology (Karolinska Institutet). After being awarded his PhD in 1965, he spent his postdoctoral period in Oxford (UK) 1966-1967. He moved to the Netherlands in 1972, where he worked as a professor of Neurophysiology at the University of Amsterdam and, later, as a professor of Medical Physiology at the University of Groningen. Most of his research work has concerned the neuromuscular system (motoneurones and muscles), and his results have been published in many articles in international scientific journals and presented at international symposia and congresses.