Description - The Role of DNA Damage and Repair in Cell Aging by Barbara A. Gilchrest
Ageing occurs at the level of individual cells, a complex interplay between intrinsic "programming" and exogenous "wear and tear", with genetically-determined cellular capacity to repair environmentally-induced DNA damage playing a central role in the rate of ageing and its specific manifestations. In 12 chapters, "The Role of DNA Damage and Repair in Cell Aging" provides an intellectual framework for ageing of mitotic and post-mitotic cells, describes a variety of model systems for further studies, and reviews current concepts of DNA responses and their relationship to the phenomenon of ageing. As part of a series entitled "Advances in Cell Aging and Gerontology," this volume also summarizes seminal recent discoveries such as the molecular basis for Werner syndrome (a mutant DNA helicase), the complementary roles of telomere shortening and telomerase activity in cell senescence versus immortalization, the role of apoptosis in the homeostasis of ageing tissue, and the existence of an inducible SOS-like response in mammalian cells that minimizes DNA damage from repeatedly encountered injurious environmental agents.
Insights into the relationship between cellular ageing and age-associated diseases, particularly malignancies, are also provided in several chapters. This book is a single source of information for anyone interested in DNA repair, mechanisms of ageing, or certainly their intersection. Students should gain a general appreciation of these fields, but even the most senior investigators should benefit from the detailed coverage of rapidly advancing areas.
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Elsevier Science Ltd
Publisher: Elsevier Science & Technology
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Book Reviews - The Role of DNA Damage and Repair in Cell Aging by Barbara A. Gilchrest