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Description - Neurodegenerative Diseases and Metal Ions by Astrid Sigel

Neurodegenerative diseases of the human brain constitute a major demographic problem. As life expectancy increases in the developed world, so does the incidence of these disorders, affecting an increasing percentage of the ageing population. These diseases come in various forms, causing disorders of movement and coordination, provoking cognitive deterioration and resulting in psychiatric disturbances. Many of these diseases are associated both with oxidative stress, involving the formation of reactive oxygen and nitrogen species, and with alterations in the homeostasis of a number of metal ions, notably copper, iron and zinc. The last decade has not only witnessed a growing awareness of the potential threat posed by neurodegenerative diseases as a sociological and psychological problem, but also the fact that they represent a challenge for the burgeoning applications of molecular biological approaches (genomics, proteomics) to medical problems. This, of course, leads to the concept of 'molecular medicine', whereby the resolution, ultimately at the molecular level, of the causes of pathological conditions, not only determines, but directs the development of therapeutic strategies. Volume 45 in the Metal Ions in Biological Systems series focuses on the devastating effects metal ions can have on proteins and related compounds.

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Book Details

ISBN: 9780470014882
ISBN-10: 0470014881
Format: Hardback
(232mm x 162mm x 35mm)
Pages: 488
Imprint: John Wiley & Sons Ltd
Publisher: John Wiley and Sons Ltd
Publish Date: 24-Mar-2006
Country of Publication: United Kingdom

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Author Biography - Astrid Sigel

Astrid Sigel has studied languages and was an editor of the Metal Ions in Biological Systems series (until Volume 44) and also of the Handbooks on Toxicity of Inorganic Compounds (1988), on Metals in Clinical and Analytical Chemistry (1994; both with H. G. Seiler), and on Metalloproteins (2001; with Ivano Bertini) (Dekker, New York). Helmut Sigel is Emeritus Professor (2003) of Inorganic Chemistry at the University of Basel, Switzerland, and a previous editor of the MIBS series until Volume 44. He serves on various editorial and advisory boards, published over 300 articles on metal ion complexes of nucleotides, coenzymes, and other biologically relevant ligands. He lectured worldwide and was named Protagonist in Chemistry (2002) by ICA (issue 339). Among further honors are the P. Ray Award (Indian Chemical Society, of which he is also an Honorary Fellow), the Werner Award (Swiss Chemical Society), a Doctor of Science honoris causa degree (Kalyani University, India), appointments as Visiting Professor (e.g., Austria, China, UK) and Endowed Lectureships. Roland K. O. Sigel is Assistant Professor (2003) of Inorganic Chemistry at the University of Zurich, Switzerland, endowed with a Forderungsprofessur of the Swiss National Science Foundation. He received his doctoral degree summa cum laude (1999) from the University of Dortmund, Germany, working with Bernhard Lippert; thereafter he spent nearly three years at Columbia University, New York, USA, in the group of Anna Marie Pyle (now Yale University); during the six years abroad he received several fellowships from various sources. His research focuses on the structural and catalytic role of metal ions in ribozymes, especially group II introns, and on related topics. He was also an editor of Volumes 43 and 44 of the MIBS series.

Books By Astrid Sigel

Metal Ions in Biological Systems by Astrid Sigel
Hardback, January 1993
$468.90