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Description - The Ubiquitous Roles of Cytochrome P450 Proteins by Helmut Sigel

Helmut Sigel, Astrid Sigel and Roland K.O. Sigel, in close cooperation with John Wiley & Sons launch a new Series "Metal Ions in Life Sciences". There exists a whole range of books on Cytochromes P450, but none with the focus of this volume. This new volume in the Series concentrates on current hot topics in the area and tries to work out the underlying common developments. As a result the reader will find a systematic account of new results in this exciting research area. The table of contents gives an idea on the wide span of chapters, starting with overviews and the presentation of specific systems, and ending with chapters on carbon-carbon bond cleavage by P450 sytems, drug metabolism as catalyzed by P450 systems, decomposition of xenobiotics by P450 enzymes and design and engineering of new P450 systems.

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Book Details

ISBN: 9780470016725
ISBN-10: 0470016728
Format: Hardback
(235mm x 161mm x 37mm)
Pages: 678
Imprint: Wiley-Blackwell
Publisher: John Wiley and Sons Ltd
Publish Date: 23-Mar-2007
Country of Publication: United States

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Author Biography - Helmut Sigel

Astrid Sigel has studied languages and was an editor of the Metal Ions in Biological Systems series (until Volume 44) and also of the Handbooks on Toxicity of Inorganic Compounds (1988), on Metals in Clinical and Analytical Chemistry (1994; both with H.G. Seiler), and on Metalloproteins (2001; with Ivano Bertini) (Dekker, New York). Helmut Sigel is Emeritus Professor (2003) of Inorganic Chemistry at the University of Basel, Switzerland, and a previous editor of the MIBS series until Volume 44. He serves on various editorial and advisory boards, published over 300 articles on metal ion complexes of nucleotides, coenzymes, and other ligands of biological relevance, and lectured worldwide. He was named Protagonist in Chemistry (2002) by ICA (issue 339); among further honors are the P. Ray Award (Indian Chemical Society, of which he is also an Honorary Fellow), the Werner Award (Swiss Chemical Society), a Doctor of Science honoris causa degree (Kalyani University, India), appointments as Visiting Professor (e.g., Austria, China, UK) and Endowed Lectureships. Roland K.O. Sigel is Assistant Professor (2003) of Inorganic Chemistry at the University of Zurich, Switzerland, endowed with a Forderungsprofessur of the Swiss National Science Foundation. He received his doctoral degree summa cum laude (1999) from the University of Dortmund, Germany, working with Bernhard Lippert; thereafter he spent nearly three years at Columbia University, New York, USA, in the group of Anna Marie Pyle (now Yale University); during the six years abroad he received several fellowships from various sources. His research focuses on the structural and catalytic role of metal ions in ribozymes, especially group II introns, and on related topics. He was also an editor of Volumes 43 and 44 of the MIBS series.

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