Description - Organic Reactions, Volume 73 by Dennis G. Hall
Allylic boron compounds have gained a prominent position as a truly practical class of synthetic reagents in the past twenty-five years. Their main application as a method for the stereoselective synthesis of homoallylic alcohols by allyl-transfer to carbonyl compounds is essentially unmatched. In this process, a new carbon-carbon bond is formed, and up to two new stereogenic centers are created in a predictably controlled manner. Highly effective and general enantioselective variants are available, with countless applications in the total syntheses of polyacetate and polypropionate natural products. Furthermore, the residual allylic unit can be manipulated through a number of different transformations such as oxidative cleavage, olefin metathesis, hydrometalations, and many others. The discovery of Lewis and Bronsted acid catalyzed manifolds recently, has opened new doors for further development of this important reaction. This book provides an up-to-date, comprehensive survey of the literature of this rich chemistry as it pertains to organic synthesis.
Consistent with the goal of Organic Reactions, the content and presentation emphasize the preparative aspects of the reactions, giving considerable attention to the scope and limitations of the individual transformations along with detailed experimental procedures. A tabular survey of all examples of carbonyl allylboration used in organic synthesis is presented in nine tables organized by type of allylic boron reagent with listings within each table according to increasing carbon number of the carbonyl substrates.
The literature is covered through December 2010, including a new listing of nearly 200 literature citations that supplement the original coverage of 834 references used in the earlier hard cover version of the chapter. Allylboration of Carbonyl Compounds is intended to be a useful, easily read reference book for all practitioners of synthetic organic chemistry working in academic and industrial laboratories.
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(234mm x 160mm x 34mm)
Publisher: John Wiley and Sons Ltd
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Book Reviews - Organic Reactions, Volume 73 by Dennis G. Hall
Author Biography - Dennis G. Hall
DENNIS G. HALL received his PhD from Universite de Sherbrooke in 1995 and is now University Professor of Chemistry at the University of Alberta, Canada. The unifying theme of his research program is the development of new synthetic and biological applications of organoboronic acid derivatives, with topics including stereocontrolled reaction methodology, catalysis, multicomponent reactions, and chemical biology.
HUGO LACHANCE received his PhD from the University of Alberta in 2006 under the supervision of Prof. Dennis Hall. He is now Scientific Coordinator at Pharmaqam and Adjunct Professor at Universite du Quebec a Montreal. His research interests include asymmetric methodology, bioactive natural products, biological target identification, and protein labeling.
Scott E. Denmark received his undergraduate degree from the Massachusetts Institute of Technology in 1975 and his graduate degree (D.Sc. Tech.) from the ETH-Zurich in 1980. He joined the faculty at Illinois in the same year. His research interests are in structural, synthetic and mechanistic organic chemistry.