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This book describes the role of the neutrophil in infection and inflammation and provides an up-to-date review of the biochemistry and physiology of these cells, highlighting the mechanisms by which they seek out and destroy pathogenic micro-organisms. The development of these cells during haematopoiesis is described and the mechanisms which lead to the production of reactive oxidants and the intracellular signal transduction systems which lead to the cell's activation are reviewed. The book also discusses recent discoveries concerning the role of cytokines in the regulation of neutrophil function together with the importance of the neutrophil as a generator of inflammatory cytokines. Finally there is a description of the biochemical defects that give rise to some of the neutrophil-associated human diseases.

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Book Details

ISBN: 9780521018500
ISBN-10: 0521018501
Format: Paperback
(228mm x 152mm x 17mm)
Pages: 320
Imprint: Cambridge University Press
Publisher: Cambridge University Press
Publish Date: 22-Aug-2005
Country of Publication: United Kingdom

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Books By Author Steven W. Edwards