1300 36 33 32

An important problem in computational biology is identifying short DNA sequences (mathematically, 'words') associated to a biological function. One approach consists in determining whether a particular word is simply random or is of statistical significance, for example, because of its frequency or location. This book introduces the mathematical and statistical ideas used in solving this so-called exceptional word problem. It begins with a detailed description of the principal models used in sequence analysis: Markovian models are central here and capture compositional information on the sequence being analysed. There follows an introduction to several statistical methods that are used for finding exceptional words with respect to the model used. The second half of the book is illustrated with numerous examples provided from the analysis of bacterial genomes, making this a practical guide for users facing a real situation and needing to make an adequate procedure choice.

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Book Details

ISBN: 9780521847292
ISBN-10: 052184729X
Format: Hardback
(228mm x 152mm x 16mm)
Pages: 158
Imprint: Cambridge University Press
Publisher: Cambridge University Press
Publish Date: 13-Oct-2005
Country of Publication: United Kingdom

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