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It is essential to minimize damage to normal tissues during radiation therapy and many strategies have been employed in finding the best methods for radioprotection. This book integrates chemical, biological, and clinical perspectives on these strategies and developments, providing a comprehensive treatise. It emphasizes new concepts in radioprotection, aiming to inspire further basic science and clinical progress in radioprotector research. Radioprotectors: Chemical, Biological, and Clinical Perspectives includes the following topics: * Early research on radioprotectors * WR-2721, an aminothiol prodrug, as a radioprotector * New results with naturally occurring thiols * Nitroxides as effective radioprotectors in vitro and in vivo * Radioprotection observed with radical scavengers or antioxidants * Bone marrow radioprotection with cytokines and biological modifiers * Multiple mechanisms of altering radiation response by eicosanoids * Vascular response to radiation and the importance of vascular damage to normal tissue * Modifiers of radiation-induced apoptosis * Survey of clinical trials with radioprotectors Radiation biologists and oncologists, cancer researchers, and toxicologists will benefit from the findings discussed and strategies for future research.

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Book Details

ISBN: 9780849347566
ISBN-10: 0849347564
Format: Hardback
(235mm x 156mm x 25mm)
Pages: 448
Imprint: CRC Press Inc
Publisher: Taylor & Francis Inc
Publish Date: 29-Dec-1997
Country of Publication: United States


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