The combined biography of Drs Jadad and Enkin: There is a 40-year difference in age between us and we come from vastly different backgrounds. Nevertheless, during more than a decade we have recognized the extent to which our paths and thinking have converged. We first noticed this in Oxford with our mutual interest in systematic reviews and confirmed it at McMaster University as we became painfully aware of the pitfalls of over reliance on quantitative evidence and its limited influence on health care. During the past 5 years, our focus has been more on the value of rhetoric, information and communication technologies, complex systems and the importance of effective communication in the health system. Over the years, we have grown together in our understanding, have worked together on a variety of projects, and mutually reinforced our views on clinical evidence. We are happy to share our expanding vision of randomized trials in this new edition of the book. Alejandro R Jadad MD, DPhil, FRCPC Alex Jadad's work helps improve health and wellness for all, through innovative uses of information and communication technologies. He is a physician, researcher, educator and public advocate. He obtained a doctoral degree from Oxford University for work on meta-analysis of clinical trials, and was the founding Director of the McMaster Evidence-based Practice Centre. He developed "The Jadad Scale" (the most widely used tool to assess clinical trial quality in the world); the Centre for Global eHealth Innovation; and a virtual platform for global collaboration, and to enable the public to shape the health system and society, worldwide. Murray W Enkin MD, FRCSC, FACOG, DSc. (hon), LLD (hon) Murray Enkin is Professor Emeritus, Departments of Clinical Epidemiology and Biostatistics, Obstetrics and Gynecology, in the Faculty of Health Sciences, McMaster University. He has been a rural family doctor, obstetrician/gynecologist, and health care researcher, and is a co-author of three books, including Effective Care in Pregnancy and Childbirth, regarded as one of the most influential books in medicine and one of the foundational pillars of evidence-based decision-making. Dr. Enkin is concerned about the risks associated with over reliance on quantitative evidence and its influence on health care, a view shared by Dr. Jadad.