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Tuberous sclerosis is the prototype of a category of malformations uniquely characterized by disturbances in cellular differentiation and growth. It presents with a complex association of different neurological phenotypes, including seizures, cognitive impairments and autism. It is important not only because it is a relatively common hereditary neurological disease with high morbidity, but because it has implications in other pathological processes, such as dysplasia and neoplasia, hamartoma formation and other disturbances in morphogenic processes. This book correlates genetic data and basic science, covers clinical presentation, reviews the historical background and diagnostic criteria, and presents an overview of neuropathology, molecular genetics and neurobiology in order to give a better understanding of the pathogenesis of the disease. Paediatricians and child neurologists will find this book uniquely useful.

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Book Details

ISBN: 9781898683391
ISBN-10: 1898683395
Format: Hardback
(238mm x 155mm x 28mm)
Pages: 328
Imprint: Mac Keith Press
Publisher: Mac Keith Press
Publish Date: 1-Jan-2003
Country of Publication: United Kingdom


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Author Biography - Paolo Curatolo

Professor of Pediatric Neurology and Psychiatry, Department of Neuroscience, University of Rome Tor Vergata; Head of the Section of Pediatric Neurology, University of Rome Tor Vergata.