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In this first comprehensive resource to cover the application of single molecule techniques to biological measurements, the pioneers in the field show how to both set up and interpret a single molecule experiment. Following an introduction to single molecule measurements and enzymology, the expert authors consider molecular motors and mechanical properties before moving on to the applications themselves. Detailed discussions of studies on protein enzymes, ribozymes and nucleic acids are also included.

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Book Details

ISBN: 9783527312887
ISBN-10: 3527312889
Format: Hardback
(249mm x 180mm x 22mm)
Pages: 346
Imprint: Wiley-VCH Verlag GmbH
Publisher: Wiley-VCH Verlag GmbH
Publish Date: 29-Jul-2007
Country of Publication: Germany


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Author Biography - Toshio Yanagida

Toshio Yanagida did his undergraduate and graduate studies in semi-conductor physics at Osaka University (Osaka, Japan). He then switched to biophysics in 1970 to pursue a career in basic science. He is now professor and Dean of the Osaka University Graduate School of Frontier Biosciences, and project leader at both the Single Molecule Processes Project and the Kansai Advanced Research Center Communications in Japan. His teams are leading the development of single-molecule detection techniques to investigate the molecular motor of contracting muscle. Professor Yanagida is a founding editor of the Journals "Single Molecules" and "Small". For his scientific achievements, he has received numerous awards, among them the Japan Academy Award and the Japanese Imperial Award. Yoshiharu Ishii studied physics and biophysics at the Universities of Tokyo and Nagoya, Japan. From 1983 onwards he worked at the Boston biomedical research Institute, USA, returning to Japan in 1992 to pursue his research career in applied biophysics. He organized research teams "Biomotron", "Single Molecule Processes,", and "Soft Nano-machines" with Prof. Yanagida to develop single molecule detection techniques. He is currently a research manager in Core Research for Evolutional Science an Technology (CREST) in Japan Science and Technology agency (JST). Dr. Ishii is an editorial board member of the journal "Open Biochemistry".