Description - Mechanisms of Drug Resistance in Epilepsy by Novartis Foundation
Drug resistance in epilepsy is an important clinical problem. About 30 per cent of patients diagnosed as having epilepsy fail to respond to prescribed antiepileptic drugs and continue to have seizures. But despite the size of the problem, remarkably little attention has been paid to the biological basis of refractory epilepsy. Recent work has shown that brain tissue from some patients with epilepsy shows increased expression of a protein that mediates drug resistance in cancer, P glycoprotein. But while resistance in cancer has been extensively studied, and trials of reversal of resistance have been undertaken with some success, resistance in epilepsy has only just begun to be addressed. This book brings together epilepsy researchers and oncologists, with a view to stimulating further work on drug resistance in epilepsy. Bridging the two fields, the discussions contained in this book should be of interest to those working on cancer resistance and refractory epilepsy alike.
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(238mm x 158mm x 17mm)
John Wiley & Sons Ltd
Publisher: John Wiley and Sons Ltd
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Book Reviews - Mechanisms of Drug Resistance in Epilepsy by Novartis Foundation