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Description - Polycystic Kidney Disease by Jinghua Hu

This volume focuses on the investigatory methods applied to autosomal dominant polycystic kidney disease (ADPKD), one of the most common human genetic diseases. ADPKD is caused by mutations in PKD1 and TRPP2, two integral membrane proteins that function as receptor/ion channels in primary cilia of tubular epithelial cells. Thus, ADPKD belongs to ciliopathies, a group of disorders caused by abnormal cilia formation or function. This proposed book will cover the state-of-the-art methods ranging from molecular biology, biochemistry, electrophysiology, to tools in model animal studies.

Key Features

  • Explores the role of cilia in polycystic kidney disease
  • Focuses on myriad state-of-the-art methods and techniques
  • Reviews specific mutations integral to this autosomal genetic disease
  • Includes discussions of model systems

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Book Details

ISBN: 9781138603899
Format: Hardback
(235mm x 156mm x mm)
Pages: 346
Imprint: CRC Press
Publisher: Taylor & Francis Ltd
Publish Date: 14-Nov-2019
Country of Publication: United Kingdom

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