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Description - Sample Sizes for Clinical Trials by Steven A. Julious

Drawing on various real-world applications, Sample Sizes for Clinical Trials takes readers through the process of calculating sample sizes for many types of clinical trials. It provides descriptions of the calculations with a practical emphasis. Focusing on normal, binary, ordinal, and survival data, the book explores a range of trials, including superiority, equivalence, non-inferiority, bioequivalence, and precision for both parallel group and crossover designs. The author discusses how trial objectives impact the study design with respect to the derivation of formulae for sample size calculations. He uses real-life studies throughout to show how the concepts and calculations can be employed. This work underscores the importance of sample size calculation in the design of a clinical trial. With useful calculation tables throughout, it enables readers to quickly find an appropriate formula, formula application, and associated worked example.

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Book Details

ISBN: 9781584887393
ISBN-10: 1584887397
Format: Hardback
(235mm x 156mm x mm)
Pages: 317
Imprint: Chapman & Hall/CRC
Publisher: Taylor & Francis Ltd
Publish Date: 26-Aug-2009
Country of Publication: United States

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Author Biography - Steven A. Julious

Steven A. Julious is a Senior Lecturer in Medical Statistics at the University of Sheffield. His research interests include clinical trials, clinical trial design, early phase trials, and the development of new methodologies related to clinical trials.